Glossary of Multiple Myeloma Terms | The MMRF

Glossary

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  • a

  • Absolute neutrophil count (ANC)
    The number of white blood cells in the blood that are neutrophils; a low ANC indicates neutropenia and a possible increased risk of infection.
  • Accelerated Approval
    Designation assigned to a drug by the Food and Drug Administration (FDA) intended to make promising products for life-threatening diseases available on the market on the basis of preliminary evidence prior to formal demonstration of patient benefit. In this case, clinical studies  and subsequent FDA evaluation are based on a surrogate marker that is considered likely to predict patient benefit. The marketing approval that is granted may be considered provisional, and a company may be required to complete additional clinical studies that formally demonstrate patient benefit.
  • Actionable target
    A genetic mutation that causes cancer to develop and for which a drug can block its cancer-causing activity.
  • Active immunotherapy
    Type of immunotherapy that stimulates the body to mount an immune response; an example is a vaccine.
  • Active multiple myeloma (MM)
    Multiple myeloma in which the percentage of plasma cells in the bone marrow is greater than 10% and in which the patient shows one or more CRAB symptoms (see definition at CRAB).
  • Adaptive immunity
    The part of the immune system that is composed of highly specialized cells designed to recognize foreign invaders and attack them any time they enter the body.
  • Adhesion molecules
    Complementary molecules present on cell surfaces that allow cells to interact with each other, acting in the same way as a lock and key.
  • Adjuvant
    (1) When referring to vaccines, an adjuvant is a substance administered as part of, or along with, a vaccine that increases its effectiveness by strengthening the immune response against the vaccine. (2) Adjuvant therapy also refers to a treatment that is given in addition to a standard treatment regimen to increase its effectiveness.
  • Adriamycin (doxorubicin)
    A type of chemotherapy which is given intravenously (into a vein). It is part of an older type of myeloma treatment called VAD. VAD consists of the combination of Vincristine (another chemotherapy drug), Adriamycin, and dexamethasone which is a steroid.
  • Adverse event (AE)
    Any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease that occurs after a medical treatment or procedure; AEs may or may not be related to the treatment or procedure. An adverse event is a term that is a unique representation of a specific event used for medical documentation and scientific analyses. See Grade 1-4 adverse events.
  • Albumin
    Major protein found in the blood; albumin level can indicate a person's overall health and nutritional status.
  • Alkeran®
    See Melphalan.
  • Allogeneic stem cell transplant
    Procedure in which stem cells from another person are transplanted into a patient.
  • Allograft
    Allogeneic stem cell transplant.
  • Aloxi® (palonosetron)
    A type of medicine used to prevent or treat nausea and vomiting as a result of cancer treatment. It is given intravenously (into a vein).
  • Alpha interferon
    Cytokine produced by T cells that exhibits a variety of immunomodulating effects, including suppression of cell growth and enhancement of tumor cell killing.
  • Amyloid protein
    Fiber-like substance, often composed of light chains and other proteins, that can accumulate in and damage various tissues and organs.
  • Amyloidosis
    Condition related to multiple myeloma whereby a patient’s light chains can clump together to form insoluble protein fibers known as amyloid fibrils. Amyloid fibrils can accumulate in various tissues and organs, disrupting their normal functions. Rarely, patients with myeloma may also develop amyloidosis.
  • Anemia
    Decrease in the number of red blood cells in the blood.
  • Angiogenesis
    Growth of new blood vessels.
  • Anthracycline
    Class of anticancer drugs that includes doxorubicin (Adriamycin®) and related compounds such as daunorubicin and daunomycin.
  • Antibody
    Protein produced by plasma cells that helps protect the body from infection and disease (also called immunoglobulin; see also monoclonal antibody)
  • Antibody-drug conjugate (ADC)
    A monoclonal antibody that is coupled to a drug (such as a toxin, a radioactive isotope, or a chemotherapy); one example is Blenrep.
  • Antiemetic
    Drug that prevents or relieves nausea and vomiting.
  • Antigen
    Substance that stimulates the production of an antibody to which it subsequently binds.
  • Antimicrobial
    Drug that kills or slows the growth of bacteria.
  • Anzemet® (dolasetron)
    A type of medicine used to prevent or treat nausea and vomiting as a result of cancer treatment. It is given intravenously (into a vein).
  • Apheresis
    A procedure in which blood is taken from a patient, part of the blood (such as white blood cells) is taken out, and the rest of the blood is returned to the patient.
  • Apoptosis
    Programmed (natural) cell death.
  • Asthenia
    Marked loss of body strength.
  • Autograft
    Autologous stem cell transplant.
  • Autoimmune diseases
    Illnesses that occur when the body tissues are attacked by its own immune system.
  • Autologous
    From the patient. In myeloma, this term usually refers to a commonly used type of stem cell transplantation where the patient serves as their own donor.
  • Autologous stem cell transplant (ASCT)
    Procedure in which stem cells collected from a patient are transplanted back into that patient; the most common type of transplant performed in myeloma.
  • Autologous transplant
    Transplant whereby the patient’s own cells or tissues are collected and reinfused or transplanted.

  • b

  • B cell
    White blood cell that gives rise to a plasma cell (plasma cells produce antibodies, which fight infections).
  • B-cell maturation antigen (BCMA)
    A protein found on the surface of myeloma cells.
  • B lymphocyte
    See B cell.
  • Balloon kyphoplasty
    Procedure used to treat fractures in the spine (see kyphoplasty).
  • Basic fibroblast growth factor (bFGF)
    Growth factor that promotes angiogenesis (the growth of new blood vessels); also known as FGF-2.
  • Bcl-2
    Protein made by cancer cells that is thought to block chemotherapy-induced cell death.
  • Bence-Jones protein
    See Light chain.
  • Beta 2-microglobulin (ß2-microglobulin or ß2-M)
    Protein normally found on the surface of various cells in the body; levels of ß2M in the blood are elevated in inflammatory conditions and in certain blood cell disorders, such as multiple myeloma.
  • Biaxin (clarithromycin)
    Type of antibiotic.
  • Bispecific antibody
    A monoclonal antibody that can simultaneously bind to two different cell surface proteins.
  • Bisphosphonate
    Type of drug used to treat osteoporosis and bone disease.
  • Blood urea nitrogen (BUN)
    Byproduct of protein metabolism that is normally filtered out of the blood and found in the urine; elevated levels in the blood can indicate decreased kidney function.
  • Bone marrow
    Soft, spongy tissue found in the center of many bones and the site of blood cell production.
  • Bone marrow aspiration
    Removal of fluid and cells of the bone marrow via use of a needle.
  • Bone marrow biopsy
    Removal of a sample of bone marrow for examination; performed using a needle.
  • Bone remodeling
    Process of normal bone maintenance whereby old, worn-out bone is broken down and removed by osteoclast cells and new bone is formed by osteoblast cells.
  • Bone resorption
    The normal process of breaking down of bone by osteoclasts during bone remodeling. Bone resorption can be increased in myeloma.
  • Bone (skeletal) survey
    Series of X-rays of the skull, spine, arms, ribs and legs.

  • c

  • C-reactive protein (CRP)
    Protein produced by the liver when there is an inflammatory process occurring in the body. Serum levels of CRP are increased in various inflammatory diseases, degenerative diseases and cancers, including myeloma. Lower levels are associated with a more favorable prognosis in myeloma.
  • Calcium
    Mineral that is important in bone formation; elevated serum levels occur when there is bone destruction.
  • Cancer vaccine
    A cell-based or protein-based immunotherapy in which cancer cells (such as myeloma cells) are mixed with immune-stimulating agents or engineered and injected into a patient to boost the immune response.
  • Catheter
    A thin flexible tube that is inserted into the body. For example, it may be inserted into a vein in order to give drugs, blood or nutrients. Catheters are also used to take blood or empty the bladder.
  • CD34+
    Cell surface marker. CD stands for cluster of differentiation and the 34+ indicates a specific antigen for which this cell is positive. Stem cells are CD34+.
  • Checkpoint inhibitor
    A naked antibody that interferes with proteins that enable a cancer cell to hide from, overpower, or resist the immune system; by blocking these proteins, the “brakes” on the immune system are released and immune cells are able to kill cancer cells.
  • Chemistry profile
    Blood test that determines levels of several chemical compounds in the blood at one time. Of particular importance in myeloma are levels of blood urea nitrogen (BUN), calcium, creatinine and lactate dehydrogenase (LDH).
  • Chemobrain
    Constellation of symptoms, such as loss of memory, difficulty with language and lack of concentration, that have been reported by cancer patients who receive chemotherapy; also known as cognitive dysfunction.
  • Chemotherapy
    The use of drugs to kill rapidly dividing cells, such as cancer cells.
  • Chimeric antigen receptor T (CAR T) cell therapy
    A form of immunotherapy in which a patient’s immune cells (mostly T cells) are collected, engineered in a lab to be better able to identify and attack myeloma cells, and then returned to the patient; examples are Abecma and Carvykti.
  • Chromosomal abnormality
    Defect or variation in a chromosome; in some people with multiple myeloma, a piece of one or more chromosomes may be missing or swapped with another piece from a different chromosome; deletion p13 and t(4;14) are examples of chromosomal abnormalities.
  • Chromosomal deletion
    Chromosomal abnormality in which a segment of a chromosome is missing; del(17p) is an example of a chromosomal deletion.
  • Chromosomal translocation
    Chromosomal abnormality in which segments of two chromosomes switch positions; t(4;14) and t(11;14) are examples of chromosomal translocations.
  • Chromosome
    Thread-like structure in a living cell that contains DNA (genetic information).
  • Chromosome analysis (cytogenetic testing)
    Laboratory test that measures the number and structure of chromosomes.
  • Clinical trial
    A study of the safety and effectiveness of a therapeutic agent using consenting human subjects.
  • Clonal tide
    Increase and/or decrease in the number of myeloma clones in response to treatment.
  • Clone
    A specific kind of myeloma cell within a subtype.
  • Colony-stimulating factor (CSF)
    Growth factor that stimulates the bone marrow to produce white blood cells.
  • CoMMpass Study
    Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profiles study; a large-scale, longitudinal study initiated in 2011 to better understand the molecular and genetic components of multiple myeloma at diagnosis and at other key time points.
  • Comorbidity
    A medical condition that occurs while another condition is present.
  • Complete blood count (CBC)
    Blood test that measures the number of red blood cells, white blood cells, and platelets in the blood and the relative proportions of the various types of white blood cells.
  • Complete metabolic panel (CMP)
    Blood test that measures levels of albumin, calcium, lactate dehydrogenase (LDH), blood urea nitrogen (BUN), and creatinine to assess bone status, the extent of disease, and the function of the kidneys and liver (also known as chemistry profile).
  • Complete remission
    See complete response
  • Complete response (CR)
    A treatment outcome in which the level of plasma cells in the bone marrow is no more than 5%, there is no evidence of myeloma proteins in the serum or urine as measured by standard laboratory techniques, and all signs and symptoms of cancer have disappeared (though cancer still may be in the body).
  • Computed tomography (CT)
    Imaging technique that uses a computer to generate three-dimensional x-ray pictures (also referred to as computerized axial tomography [CAT]).
  • Computerized axial tomography (CAT)
    See Computed tomography (CT).
  • Conditioning regimen
    Combination of chemotherapy and/or radiation treatments administered over a period of several days prior to stem cell transplantation in order to kill cancer cells.
  • Consolidation Therapy
    Anti-myeloma treatment given after the initial therapy in order to further reduce the number of cancer cells.
  • Conventional chemotherapy
    Administration of chemotherapy at a dose that does not completely destroy the bone marrow; also known as standard-dose chemotherapy.
  • Cord blood transplant
    Type of transplant where the stem cells are obtained from the umbilical cord and placenta (afterbirth) following the delivery of a baby. These cells are frozen for future use.
  • Corticosteroid
    A potent class of drugs used to reduce inflammation, suppress the immune system, and fight tumors; dexamethasone and prednisone are examples of corticosteroids.
  • Coumadin® (also known as warfarin)
    A pill that is a type of blood thinner. It is used to prevent blood clots.
  • CR
    See complete response
  • CRAB
    Acronym for the following group of clinical indicators of organ damage: increased calcium level, renal (kidney) failure, anemia, bone lesions; the presence of one or more of these indicators can help establish a diagnosis of multiple myeloma.
  • Creatinine
    Product of energy metabolism of muscle that is normally filtered out of the blood and found in the urine; elevated levels in the blood can indicate decreased kidney function.
  • Cryoglobulinemia
    Condition that occurs when a myeloma protein is of a specific type that comes out of solution as particles when exposed to cold temperatures. These particles may block small blood vessels and cause symptoms such as pain and numbness in the fingers and toes in cold weather.
  • Cryopreservation
    A method of freezing cells that permits storage over an extended period.
  • Cure
    Treatment outcome where there is complete and lasting recovery from disease. This has not yet been achieved in myeloma.
  • CureCloud
    A direct-to-patient research effort aimed at enrolling 5,000 patients with multiple myeloma from whom comprehensive molecular and immune analyses will be generated from blood samples and the resulting data aggregated with the correlating clinical information.
  • Cutaneous T-cell lymphoma (CTCL)
    A type of non-Hodgkin’s lymphoma which is a cancer of the immune system.
  • Cyclooxygenase-2 (COX-2)
    A protein that acts as an enzyme to enhance the production of prostaglandins responsible for promoting inflammation.
  • Cyclophosphamide
    Type of chemotherapy. Brand names include Cytoxan® and Neosar®.
  • Cyclosporine
    Immunosuppressive drug used following allogeneic transplants that helps prevent graft-versus-host disease (donor cells attacking the recipient’s cells).
  • Cytogenetic testing
    See Chromosome analysis.
  • Cytogenetics
    The number and structure of chromosomes in cells.
  • Cytokine
    A protein produced and secreted by cells of the immune system (for example, interleukins).
  • Cytokine release syndrome (CRS)
    A common, infection-like side effect following infusion of CAR T cells in which a patient experiences fevers, chills, and low blood pressure.
  • Cytoxan®
    See Cyclophosphamide.

  • d

  • Decadron® (dexamethasone)
    Type of corticosteroid used in the treatment of myeloma. Decadron is part of many combination chemotherapy regimens.
  • Deep vein thrombosis (DVT)
    Serious condition where a blood clot forms in one of the deep veins in the body, usually in the legs or lower abdomen. DVT is treated with a blood thinner (also called an anticoagulant).
  • Demographic
    A particular group within a population.
  • Dendritic cell
    A type of immune cell that that is found in tissues (such as the skin) and that boosts immune responses by showing parts of proteins on its surface to other cells of the immune system.
  • Dexamethasone
    A steroid used in the treatment of multiple myeloma, often in combination with another anti-myeloma drug. Decadron® is one brand of dexamethasone.
  • Dialysis
    Procedure in which blood is removed from a patient, purified, and returned to the patient; commonly used in patients with kidney disease, this procedure essentially replaces the function of the damaged or diseased kidney.
  • Disease-free survival
    The length of time during and after treatment in which a patient is living with a disease that does not get worse; also referred to as progression-free survival (PFS).
  • Disease status
    Whether a patient has already received therapy for their myeloma disease and if so, what was the outcome.
  • DMSO
    Dimethyl sulfoxide, a colorless chemical used for cryopreservation of stem cells. When introduced into the body, may cause unpleasant or even serious toxic effects.
  • DNA (deoxyribonucleic acid)
    Genetic material of the cell located in the chromosomes.
  • Donor Lymphocyte Infusion (DLI)
    Experimental therapy used following high-dose chemotherapy and allogeneic stem cell transplant; involves the administration of additional immune cells from the same allogeneic donor to help attack myeloma cells and control the disease.
  • Doxil® (doxorubicin HCl liposome injection)
    A chemotherapy drug used in cancer treatment. It is a reformulated version of doxorubicin (Adriamycin®), a cancer drug that was used for many years in traditional chemotherapy regimens, including VAD (vincristine, Adriamycin, and dexamethasone) in myeloma.

  • e

  • Electrolytes
    Electrolytes are minerals that are present in the body such as sodium, potassium, chloride and bicarbonate. The balance of electrolytes is essential for the normal function of organs. Diarrhea may cause electrolyte depletion.
  • Electrophoresis (EP)
    Laboratory test used to measure the levels of proteins in the blood or urine; uses an electrical current to sort proteins by their charge.
  • Emend® (aprepitant)
    A type of medicine used to prevent or treat nausea and vomiting as a result of cancer treatment. It may be given either orally or intravenously (into a vein).
  • Emerging therapy
    New treatment that is being investigated in clinical trials.
  • End Point
    The specific result that is being measured by a clinical trial.
  • Endothelial cell
    Type of cell that lines blood vessels.
  • Engraftment
    When stem cells infused into the body start to grow and make new blood cells.
  • Enteritis
    Stomach pain or cramps caused by an inflammation of the small intestine.
  • Erythropoiesis
    The production of red blood cells by the bone marrow.
  • Erythropoietin
    Growth factor that stimulates the bone marrow to produce red blood cells.
  • Esophagitis
    Heartburn caused by an irritated esophagus (tube leading from the mouth to the stomach).
  • Event-free survival (EFS)
    Term used in clinical trials to indicate how long a patient remains free of certain negative events, such as recurrence, progression, complications or death.
  • Expanded access
    Refers to any of the procedures initiated by the Food and Drug Administration (i.e., compassionate use, parallel track and treatment IND) that distributes experimental drugs to patients who are failing on currently available treatments for their condition and are unable to participate in ongoing clinical trials.
  • Extramedullary disease
    Myeloma cells found in other organs of the body beyond the bone marrow.

  • f

  • Farydak® (Panobinostat)
    Farydak® is a histone deacetylase inhibitor that is administered in combination with Velcade® (bortezomib) and dexamethasone. It is indicated for the treatment of patients with multiple myeloma who have received at least 2 prior regimens, including Velcade and an immunomodulatory agent. This indication was approved by the FDA on February 23, 2015, under accelerated approval based on progression-free survival.
  • Fast Track designation
    Status assigned by the Food and Drug Administration (FDA) to a drug or product in clinical trials signifying that the FDA will facilitate and expedite the development and review of the application for the approval of the new drug. Fast track status is usually reserved for drugs that are intended for the treatment of serious or life-threatening conditions and which demonstrate the potential to address an unmet medical need.
  • Febrile neutropenia
    Presence of a low neutrophil count in the blood that is associated with fever; may indicate the presence of infection (that may be serious or life-threatening).
  • Fibroblast growth factor 2 (FGF-2)
    Growth factor that promotes angiogenesis (the growth of new blood vessels); also known as basic fibroblast growth factor (bFGF).
  • Filgrastim
    A type of growth factor that stimulates the growth of white cells in the bone marrow; also known as G-CSF (granulocyte colony stimulating factor) or Neupogen™.
  • Fluorescence in situ hybridization (FISH)
    Laboratory technique used to measure the number of copies of a specific DNA segment in a cell and the structure of chromosomes.
  • Fluoroscope
    Type of X-ray that allows viewing of bone.
  • Formulation
    The preparation of a drug.
  • Free light chain (FLC)
    Short protein (immunoglobulin light chain) that is produced by myeloma cells and found in the blood.
  • Frontline therapy
    Initial treatment given to a newly diagnosed patient (also known as induction therapy, first-line therapy, or frontline treatment).

  • g

  • Genomic profile
    The complete set of genetic material within an individual.
  • Genomic sequencing
    Study of DNA sequences of myeloma cells to detect mutations and to see how that DNA changes over time.
  • Genomic testing
    The process of analyzing and identifying the structure of the genetic code (see also sequencing).
  • Genomics
    Study of DNA sequences of myeloma cells to detect mutations and to see how DNA changes over time.
  • Grade 1 Adverse Event (AE)
    A mild side effect resulting from a medical therapy. Minimal or no symptoms may be present and typically medical intervention is not required.
  • Grade 2 AE
    A moderate side effect resulting from a medical therapy. Depending on the nature of the side effect, medical intervention may or may not be needed.
  • Grade 3 AE
    A severe side effect resulting from a medical therapy. This side effect typically interferes with patient functioning and requires medical intervention.
  • Grade 4 AE
    A life-threatening or disabling side effect resulting from a medical therapy. Immediate medical intervention is required.
  • Graft-versus-host disease (GVHD)
    Transplant complication in which donor immune cells attack the recipient’s cells.
  • Graft-versus-myeloma effect
    Beneficial effect of allogeneic transplants resulting from the donor cells mounting an attack on the recipient’s myeloma cells.
  • Granulocyte
    Type of white blood cell important in fighting infection. Neutrophils are the most abundant type of granulocyte.
  • Granulocyte colony-stimulating factor (G-CSF)
    A drug that stimulates the production of infection-fighting white blood cells known as granulocytes. G-CSF is used to help prevent low white blood cell counts and infection in patients receiving chemotherapy and/or stem cell transplants and is also used to help mobilize stem cells prior to stem cell transplant. In addition, it may be used to stimulate white blood cell production in patients whose white blood cell levels drop as a side effect of an anti-myeloma treatment.
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF)
    A drug that may be used as an alternate to G-CSF (see above). It stimulates the production of infection-fighting white blood cells known as granulocytes and macrophages. Similar to G-CSF, GM-CSF is used to help prevent low white blood cell counts and infection in patients receiving chemotherapy and/or stem cell transplants and is also used to help mobilize stem cells prior to stem cell transplant.
  • Growth factors
    Substance that stimulates cells to multiply. The most commonly used growth factors are red blood cell growth factors (also known as erythropoietin) and white blood cell growth factors (also known as colony stimulating factors or CSFs).

  • h

  • Hand-foot syndrome (HFS)
    Skin condition noted by tingling or burning, redness, flaking, bothersome swelling, small blisters or small sores on the palms of the hands or soles of the feet. HFS is a common side effect of certain types of chemotherapy, such as doxorubicin and liposomal doxorubicin (Doxil), and is also known as palmar-plantar erythrodysesthesia (PPE).
  • Heavily pre-treated
    Refers to patients who have recently had several prior therapies for their disease.
  • Heavy chain
    The longer of the two protein chains that make up an immunoglobulin molecule.
  • Hematocrit
    A laboratory test used to determine if anemia is present; refers to the percentage of the volume of a blood sample that consists of red blood cells.
  • Hematologic
    Pertaining to the blood.
  • Hematopoiesis
    Formation and development of blood cells in the bone marrow.
  • Hematopoietic stem cell
    Cell that grows and divides to produce red blood cells, white blood cells, or platelets; found in bone marrow and blood.
  • Hemoglobin
    Oxygen-carrying substance in red blood cells.
  • Heparanase
    Enzyme produced by tumor cells that promotes angiogenesis by loosening the “glue” that holds cells of blood vessel walls together. This, in combination with angiogenic growth factors, allows the sprouting of new blood vessels.
  • Heparin
    A type of blood thinner used to prevent blood clots. It is given as an injection. Some types may be self-administered by patients at home.
  • Hepatic impairment
    Reduced liver function that is noted by increased levels of various substances in the blood, such as bilirubin.
  • High-dose chemotherapy
    Administration of very high doses of chemotherapy that may be more effective in eliminating myeloma cells than standard treatments. High-dose chemotherapy destroys the bone marrow, which is responsible for the production of blood cells. After high-dose chemotherapy, a procedure called stem cell transplant is required to replenish blood-forming bone marrow cells.
  • High risk myeloma
    A type of myeloma where there is some feature that indicates a worse prognosis. For example, certain types of abnormalities in the DNA are associated with more aggressive disease. In addition, elevated blood levels of a protein called beta 2-microglobulin are also associated with worse prognosis.
  • Hypercalcemia
    Presence of elevated levels of calcium in the blood; occurs as a result of bone destruction.
  • Hypercalcemia of malignancy (HCM)
    Condition occurring in various forms of cancer noted by elevated levels of calcium in the blood due to increased bone destruction; also known as tumor-induced hypercalcemia (TIH).
  • Hyperdiploidy
    Extra copies of one or more chromosomes.
  • Hyperviscosity syndrome
    Condition that can occur in myeloma whereby the protein concentration in the blood becomes very high and the blood becomes very thick and sticky. Symptoms can include shortness of breath, confusion, and chest pain.
  • Hypothyroidism
    Condition where the thyroid gland is less active than normal, resulting in symptoms such as a low metabolic rate and lack of energy.

  • i

  • Immune effector cell–associated neurotoxicity syndrome (ICANS)
    Common side effect of the nervous system observed after certain immunotherapy treatments, such as CAR T-cell therapy and bispecific antibody therapy, that can include confusion or delirium, expressive aphasia, motor weakness, tremor, headache, seizures, and reduced level of consciousness.
  • Immune profile
    The inherent activity of a patient’s immune system toward cancer cells.
  • Immune response
    Reaction of the cells of the body against a substance or agent (for example, bacteria, a virus, or a foreign cell) that is not recognized as part of the body.
  • Immune system
    Network of cells that protect the body from foreign substances and can destroy infected and cancerous cells.
  • Immunoelectrophoresis
    See Immunofixation electrophoresis.
  • Immunofixation electrophoresis (IFE)
    Type of electrophoresis that uses a special antibody staining technique to identify specific types of immunoglobulin and light chains; also called immunoelectrophoresis.
  • Immunoglobulin
    Protein produced by a plasma cell that that helps protect the body from infection (also called antibody).
  • Immunomodulatory agent
    Drug that affects, enhances or suppresses the immune system.
  • Immunomodulatory drugs (IMiDs)
    Drugs that fight cancer by altering the function of the immune system; examples include Thalomid, Revlimid, and Pomalyst.
  • Immunosuppressive drug
    Drug given to suppress a patient’s immune system, such as one given to prevent rejection of transplanted tissue.
  • Immunotherapy
    Prevention or treatment of disease with drugs that stimulate the immune system.
  • Induction therapy
    The first treatment a patient receives for myeloma after he or she is diagnosed; also refers to the use of anti-myeloma drugs prior to high-dose chemotherapy and stem cell transplant (see also frontline therapy).
  • Infusion Reaction
    Symptoms that sometimes develop after a patient receives intravenous drugs; commonly include chills, fever, nausea, weakness, headache, skin rash, and/or itching; although rare, severe reactions such as difficulty breathing or low blood pressure can occur.
  • Innate immunity
    The nonspecific, rapid immune response that acts as the first line of defense against disease and aids in activating adaptive immunity.
  • Institutional Review Board (IRB)
    Board designed to oversee the research process in order to protect participant safety. Made up of researchers, ethicists and lay people from the community, the board must review clinical trial protocols and the informed consent forms participants sign.
  • Interferon (IFN)
    Substance naturally produced in the body by virus-infected cells that protects noninfected cells from viral infection. Interferon also has various effects on the immune system and is used in the treatment of several cancers and infectious diseases.
  • Interleukin 1 beta (IL-1b)
    Cytokine that enhances the growth and survival of B cells and myeloma cells and promotes inflammation.
  • Interleukin 10 (IL-10)
    Cytokine involved in the growth and survival of myeloma cells.
  • Interleukin 12 (IL-12)
    Cytokine that promotes T cell function and tumor cell killing.
  • Interleukin 2 (IL-2)
    Cytokine (growth factor) produced by T-cells that stimulates the growth of T cells and B cells.
  • Interleukin 4 (IL-4)
    Cytokine that enhances the immune system’s ability to fight tumor cells.
  • Interleukin 5 (IL-5)
    A potent T-cell derived factor that stimulates the growth of B-cells.
  • Interleukin 6 (IL-6)
    Cytokine that promotes the growth and survival of myeloma cells and normal B cells.
  • Interleukin 8 (IL-8)
    Cytokine secreted by bone marrow stromal cells in myeloma patients that promotes formation of osteoclasts (bone degrading cells).
  • International Staging System (ISS)
    System for using laboratory test results to determine the severity of multiple myeloma.
  • Interventional trial
    Type of clinical trial in which participants receive specific interventions that may be medical products (such as drugs or devices) or procedures.
  • Intravenous (IV)
    Administration of a drug directly into a vein.

  • k

  • Karyotyping
    A test that looks at the number and structure of a patient’s chromosomes to identify genetic problems.
  • Kepivance® (palifermin)
    Medication that is used to protect against the development of mouth sores that are a side effect of high-dose chemotherapy. It may also reduce the duration and severity of mouth sores if they do occur.
  • Keratopathy
    Changes to a part of the eye that result in changes in the sharpness of vision.
  • Kyphoplasty
    Procedure used to treat spinal compression fractures; in this procedure a balloon is inserted into the area of compression and inflated to elevate the collapsed section; the resulting space is then filled with bone cement, which strengthens the area.
  • Kyprolis™
    A new type of proteasome inhibitor. It is in the same class of drugs as Velcade.
  • Kytril® (granisetron)
    A type of medicine used to prevent or treat nausea and vomiting as a result of cancer treatment. It is taken orally.

  • l

  • Lactate dehydrogenase (LDH)
    Enzyme found in body tissues; elevated levels in the blood indicate tissue damage and may occur in myeloma.
  • Leukine® (sargramostim)
    A brand of Granulocyte colony-stimulating factor (G-CSF) that stimulates the growth of white blood cells in the bone marrow.
  • Light chain
    The shorter of the two protein chains that make up an antibody, characterized as either kappa or lambda type; light chains produced by myeloma cells are also referred to as Bence-Jones proteins when they occur in the urine.
  • Liposome
    Bubble- or onion-like particle made out of lipids (fats) that is used to encapsulate drugs. Encapsulation helps the drug remain in the body for a longer period of time and may reduce toxicity.
  • Longitudinal study
    Repeated observations over a long time with a large number of patients.
  • Lymphocyte
    A type of immune cell made up of two main types, B cells and T cells.
  • Lymphoma
    Blood cancer that develops in the lymph nodes.

  • m

  • Macrophage
    A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.
  • Magnetic resonance imaging (MRI)
    Scanning technique that uses magnetic energy to provide detailed images of bone and soft tissue.
  • Maintenance therapy
    Treatment that is given to patients in remission over a long period of time to reduce the risk of relapse.
  • Malignant
    Cancerous, continuing to divide.
  • Marketing Authorization Application (MAA)
    Compilation of information on the safety and efficacy of a new drug that is submitted to the European regulatory agency in order to request approval to market the drug as therapy for a particular disease indication; similar to a New Drug Application (NDA), which is submitted in the United States.
  • Matrix metalloproteinases (MMPs)
    Enzymes that break down the structure of connective tissue.
  • Mechanism of action
    The specific biochemical process through which a drug produces an effect on the body.
  • Melphalan
    Type of chemotherapy often used in the treatment of myeloma (also known as Alkeran®).
  • Metastasis
    The spread of tumor cells from the initial site to other areas of the body.
  • Microvascular density (MVD)
    Measure of the number of blood vessels in the bone marrow as an indication of the degree of angiogenesis (growth of new blood vessels). A value of less than 6 blood vessels per field when viewing bone marrow cells at 400x magnification is associated with a more favorable prognosis.
  • Mini-allogeneic transplant
    Allogeneic (cells from a donor [either a sibling or a non-family member]) transplant combined with high-dose chemotherapy.
  • Mini-transplant
    See mini-allogeneic transplant.
  • Minimal (measurable) residual disease (MRD)
    Presence of small numbers of myeloma cells in the bone marrow during or after treatment, even when the patient shows no symptoms or signs of disease.
  • Minimal response
    Treatment outcome where there is less than a 50% decrease in M protein (also known as minor response).
  • Mobilization
    The process of stimulating stem cell growth to ensure that enough stem cells can be collected for transplantation.
  • Molecular complete response
    Treatment outcome in which sensitive molecular tests show no evidence of disease.
  • Monoclonal antibody
    Antibody produced in a laboratory that is used to diagnose and treat some diseases.
  • Monoclonal gammopathy of undetermined significance (MGUS)
    A condition that can occur before a patient develops or shows any symptoms of myeloma; indicated by the presence of M protein in the serum or urine, MGUS may eventually progress to myeloma.
  • Monoclonal (M) protein
    Abnormal antibody found in large quantities in the blood and urine of individuals with myeloma.
  • Morphology
    Overall appearance.
  • MP
    A therapy consisting of the combination of melphalan, a chemotherapy drug, and prednisone, a steroid. MP has been used in myeloma treatment for many years. Today, it is usually given in combination with one of the newer agents, such as Revlimid, Velcade or Thalomid.
  • Mucositis
    Inflammation of the lining of the mouth and digestive tract that often occurs after chemotherapy; can result in mouth sores and infection.
  • Mutation
    A defect or error in a gene.
  • MyCheckpoint
    A clinical trial that is being conducted to evaluate two different checkpoint inhibitors for patients with relapsed refractory multiple myeloma who have relapsed after treatment with prior therapies, including Darzalex.
  • Mycophenolate mofetil (CellCept®)
    Immunosuppressive drug used following allogeneic transplants that helps prevent graft-versus-host disease (donor cells attacking the recipient’s cells).
  • MyDRUG (Myeloma – Developing Regimens Using Genomics)
    Trial that evaluates therapies targeting actionable genomic subtypes in high-risk relapsed or refractory multiple myeloma patients using treatments that are being studied or are already approved in other cancers.
  • Myeloablation
    The killing of bone marrow by radiation or chemotherapy. This term usually refers to the complete or near-complete destruction of the bone marrow.
  • Myelodysplastic syndrome (MDS)
    A group of diseases that affect the blood. It is not related to multiple myeloma.
  • Myeloma precursor conditions
    Any of the preceding phases of active multiple myeloma, called monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM), which are characterized by changes in the cells of the bone marrow, but no symptoms or organ damage.

  • n

  • Naked antibody
    A monoclonal antibody that can bind to a cell surface protein and that has no drug or toxin attached.
  • Natural killer (NK) cell
    A type of white blood cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus.
  • Near complete response (nCR)
    Treatment outcome in which the level of plasma cells in the bone marrow is no more than 5%, but there are myeloma proteins in the serum or urine as measured by standard laboratory techniques.
  • Nephrotoxicity
    Toxicity to the kidneys.
  • Neuropathic Pain
    Chronic pain caused by damage to, or dysfunction of, nerves.
  • Neuropathy
    Disorder of the nerves that can result in abnormal or decreased sensation or burning/tingling. When the hands and feet are affected, it is referred to as peripheral neuropathy.
  • Neutropenia
    Below-normal number of neutrophils in the blood.
  • Neutrophil
    Type of white blood cell that destroys bacteria.
  • New Drug Application (NDA)
    Compilation of information on the safety and efficacy of a new drug that is submitted to the U.S. Food and Drug Administration (FDA) in order to request approval to market the drug as therapy for a disease indication.
  • Newly diagnosed disease
    Multiple myeloma that has not yet been treated.
  • Next-generation flow
    A highly sensitive test that uses bone marrow samples to detect minimal residual disease.
  • Next-generation sequencing
    A highly sensitive test that uses genomic assessment of bone marrow samples to detect minimal residual disease.
  • Non-myeloablative allogenic transplant
    See mini-allogeneic transplant
  • Nonsecretory myeloma
    Rare form of myeloma affecting about 1% of myeloma patients where the malignant plasma cells do not secrete M protein or light chains.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
    Common types of painkillers. There are both over-the-counter NSAIDs as well as prescription NSAIDs. Examples of over-the-counter NSAIDs include aspirin, Motrin® (ibuprofen) and Aleve® (naproxen)
  • Novel erythrocyte stimulating protein (NESP)
    Protein that stimulates the bone marrow to produce red blood cells.
  • Nuclear factor ?B (NF-?B)
    Key survival protein found within the cell that acts as a messenger. When a cell receives an external signal, such as a growth factor, NF-kB transfers the message to the nucleus of the cell, causing some type of response, such as cell growth.

  • o

  • Observational study
    Clinical trial in which participants are observed over a period of time to assess health outcomes.
  • Office for Human Research Protections (OHRP)
    Government office that safeguards participants in federally funded research and provides unity and leadership for many federal departments and agencies that carry out research involving human participants.
  • Orphan Drug
    Term referring to a product that treats a rare disease affecting fewer than 200,000 Americans. The Food and Drug Administration (FDA) provides this designation and incentives for companies making orphan drugs to stimulate the research, development and approval of products that treat rare diseases.
  • Osteoblast
    Bone-forming cell.
  • Osteoclast
    Bone-destroying cell that works in conjunction with bone-forming cells to repair bone.
  • Osteoclast-activating factor (OAF)
    Substance released by tumor cells that promotes the activity of bone-destroying osteoclasts. Examples of OAFs include parathyroid hormone-related peptide (PTHrP), growth factors and cytokines.
  • Osteolytic lesion
    Soft spot in the bone where bone tissue has been destroyed; appears as a hole on a standard x-ray.
  • Osteonecrosis of the jaw (ONJ)
    Death or destruction of bone tissue in the jaw due to trauma, loss of blood supply, or disease; can be associated with long-term bone-strengthening treatment in myeloma patients.
  • Osteopenia
    Decreased bone density.
  • Osteoporosis
    Bone loss typically associated with old age; can occur in myeloma.
  • Overall response rate (ORR)
    The total of all types of responses seen in a clinical study (complete response + very good partial response + partial response + minor response).
  • Overall survival (OS)
    Term used in cancer clinical trials to indicate how long a patient survives.

  • p

  • Paget’s Disease
    A bone disease that is not related to cancer. It is a chronic condition that results in enlarged and deformed bones.
  • Palifermin
    Medication that stimulates the growth of cells found in the oral cavity and skin and reduces the duration and severity of oral mucositis (inflammation of the lining of the digestive tract) after intensive chemotherapy and radiotherapy for hematologic cancers. The brand name for palifermin is Kepivance™.
  • Palliative
    Meant to reduce symptoms and relieve pain rather than to alter the course of disease.
  • Palmar-plantar erythrodysesthesia (PPE)
    See hand-foot syndrome (HFS)
  • Pamidronate (Aredia®)
    A type of bisphosphonate. Bisphosphonates are drugs that are used to treat osteoporosis as well as to prevent and treat bone problems in myeloma patients.
  • Paraprotein
    See Monoclonal protein.
  • Parathyroid hormone-related peptide (PTHrP)
    Hormone produced by certain tumors that promotes the activity of bone-destroying osteoclasts and causes increased calcium in the blood (hypercalcemia).
  • Partial response (PR)
    Treatment outcome where there is a greater than 50% decrease in M protein and disappearance of some (but not all) signs and symptoms of cancer; also referred to as partial remission.
  • PCROWD study
    A clinical trial conducted to identify changes in the cells of patients with myeloma precursor conditions (MGUS or SMM) (visit www.enroll.pcrowd.org).
  • Pegylated
    When a polyethylene glycol molecule is added on to a drug molecule. Pegylation helps a drug remain in the body for a longer period of time.
  • Performance status
    A measure of a patient’s ability to perform everyday functions and self-care.
  • Peripheral blood
    The blood that circulates throughout the body.
  • Peripheral blood stem cell (PBSC)
    Stem cells collected from the blood. The term “peripheral” means that the cells come from outside the bone marrow.
  • Peripheral blood stem cell (PBSC) transplant
    Procedure in which blood containing mobilized stem cells is collected by apheresis, stored and infused following high-dose chemotherapy and/or radiation therapy.
  • Peripheral edema
    Abnormally large amount of fluid in the circulatory system or in tissues.
  • Peripheral neuropathy
    Disorder of the nerves that can disrupt sensation or cause burning/tingling in the hands and feet.
  • Personalized medicine
    Tailoring or individualizing treatment based on an individual’s biological make up.
  • Phase I/2 study
    A clinical study that combines a phase 1 and a phase 2 trial of the same treatment. First, the phase 1 part of the trial determines a safe dose, then more patients are treated at this dosage in the phase 2 part of the study to further evaluate safety and efficacy.
  • Phase 1 study
    The first round of a clinical trial, conducted with a small number of participants to assess a drug’s safety and non-toxic dosage levels.
  • Phase 2 study
    The second stage of a clinical trial, conducted with a larger number of participants to assess a drug’s effectiveness and further evaluate its safety.
  • Phase 3 study
    The most advanced stage of drug development, conducted with a large number of participants to confirm a drug’s effectiveness, identify and monitor its side effects, compare it to commonly used treatments, and collect information that will allow the drug to be used safely; usually required for FDA approval of drugs.
  • Phase 4 study
    Clinical study conducted after a drug is approved by the Food and Drug Administration (FDA); may be conducted at the request of the FDA or by the sponsoring company for various reasons. Phase 4 studies may involve a larger patient population than that studied during earlier clinical trials; they help monitor the safety of the drug and provide ongoing technical support.
  • Placebo
    Drug or treatment that is designed to look like the medicine being tested but that does not have the active ingredient; rarely used in cancer treatment trials.
  • Plasma cell
    Antibody-secreting immune cell that develops from a B cell; in myeloma, it is this type of cell that has become cancerous or abnormal.
  • Plasmablast
    Immature plasma cell.
  • Plasmablastic morphology
    When the shape and appearance of myeloma cells are more similar to that of early immature plasma cells (plasmablasts). Absence of plasmablastic morphology typically indicates a more favorable prognosis.
  • Plasmacytoma
    Tumor made up of cancerous plasma cells that occurs in bone or soft tissue; patients with a plasmacytoma may develop multiple myeloma.
  • Plasmapheresis
    Method of removing blood plasma from the body by withdrawing blood, separating it into plasma and cells, and transfusing the cells back into the bloodstream; it is often performed when treating autoimmune conditions and may be used in myeloma.
  • Plateau phase
    When the outcome of therapy, be it a response or stable disease, has leveled off and disease parameters remain at a stable level.
  • Platelets
    Small cell fragments in the blood that help it to clot.
  • Pomalyst (pomalidomide)
    A type of immunomodulatory drug. It is in the same class of drugs as Revlimid and Thalomid.
  • Positron emission tomography (PET)
    Imaging technique in which radioactive glucose (sugar) is used to highlight cancer cells.
  • Precision medicine
    Highly specialized approach to myeloma therapy in which DNA test results are used to guide treatment.
  • Preclinical studies
    Experiments conducted in the laboratory and in animals to identify a target for therapy and to confirm its anti-cancer activity.
  • Precursor cell
    Earlier form of a cell; for example, B cells are precursors of plasma cells.
  • Prednisone
    Type of steroid used to treat myeloma. It is frequently given in combination with a chemotherapy drug called melphalan.
  • Priority Review
    Designation assigned to a drug or product by the Food and Drug Administration (FDA) stating that the FDA will review the application for approval within a target date of 6 months rather than the standard review target date of 10 months. A Priority designation is intended for drugs and products that address unmet medical needs.
  • Prognosis
    Prediction of the course and outcome of a disease.
  • Prognostic indicator
    Clinical or laboratory finding that helps determine prognosis. In myeloma, a prognostic indicator may help determine how fast the tumor is growing, the extent of disease, tumor cell biology, response to therapy, overall health status of the patient and when treatment should begin.
  • Progression-free survival (PFS)
    The length of time during and after treatment in which a patient is living with a disease that does not get worse; also referred to as disease-free survival.
  • Progressive disease
    Active myeloma that is worsening; in most cases, relapsed and/or refractory disease can be considered to be progressive disease.
  • PROMISE study
    A clinical trial conducted to identify new ways to prevent multiple myeloma in individuals with its precursor conditions (MGUS or SMM) (visit www.enroll.promisestudy.org).
  • Prophylactic
    Preventing the spread or occurrence of infection or disease.
  • Proteasome inhibitors
    Drugs that slow myeloma cell growth and kill myeloma cells by interfering with processes that play a role in cell function; examples include Velcade, Ninlaro, and Kyprolis.
  • Protocol
    Action plan for a clinical trial that includes detailed description of patients who may join the trial, the therapy that will be given and the care the patients will receive during and after the trial.
  • Pulmonary embolism
    A sudden blockage in a lung artery, usually due to a blood clot that traveled to the lung from a vein in the leg. This is a very serious condition which may be life-threatening.
  • Pyrexia
    Fever.

  • r

  • Radiopharmaceutical
    A radioactive drug used for diagnostic or therapeutic purposes.
  • Radiation therapy (or radiotherapy)
    Use of high-energy rays to kill myeloma cells; sometimes used to relieve bone pain.
  • Randomization
    Method used to prevent bias in research studies; a computer or a table of random numbers generates treatment assignments, and participants have an equal chance to be assigned to one of two or more groups (e.g., the control group or the investigational group).
  • RANK L (also known as RANK Ligand)
    Substance produced by bone marrow stromal cells and bone-forming osteoblasts that induces the development and growth of osteoclasts and contributes to the bone disease of myeloma. RANK L is blocked by Xgeva, a monoclonal antibody therapy approved in myeloma, that reduces skeletal related events.
  • Red blood cell (RBC)
    Blood cell that carries oxygen.
  • Refractory disease
    Myeloma that progresses during therapy.
  • Relapsed disease
    Myeloma that progresses after initially responding to therapy.
  • Renal Impairment
    Reduced function of the kidneys.
  • Response Rate or Overall Response
    The total percentage of patients who respond to a specific therapy in a clinical trial.
  • Revised International Staging System (R-ISS)
    System for using laboratory test results to determine the severity of multiple myeloma.
  • Revlimid® (lenalidomide)
    Oral drug with multiple anti-myeloma effects. Revlimid has been shown to be effective in newly diagnosed and relapsed or refractory myeloma alone and in combination with other drugs. It is chemically similar to an older myeloma drug called Thalomid® (thalidomide).
  • RNA (ribonucleic acid)
    Genetic material of the cell that codes for proteins.

  • s

  • Screening study
    Clinical trial that evaluates new tests for detecting cancer and other health conditions in people before symptoms are present.
  • Second-line therapy
    Treatment that is given after failure of initial therapy or after disease relapses.
  • Sequencing
    The process of analyzing and identifying the structure of the genetic code (that is, DNA and RNA).
  • Serum protein electrophoresis (SPEP)
    Test used to measure proteins in the blood or serum; uses an electrical current to separate proteins by their charge.
  • SLiM
    Acronym for the following group of clinical indicators of multiple myeloma: sixty percent or greater plasma cells in the bone marrow; an elevated free light chain ratio; MRI with more than one bone lesion; the presence of any of these indicators establishes a diagnosis of multiple myeloma
  • Smoldering (asymptomatic) multiple myeloma (SMM)
    Myeloma characterized by increased M protein and slightly increased numbers of plasma cells in the bone marrow and an absence of symptoms; patients with SMM are monitored and only treated if their disease progresses; about 5% of myeloma patients have SMM.
  • Special Protocol Assessment (SPA)
    Procedure by which the U.S. Food and Drug Administration (FDA) evaluates and provides guidance on proposed protocols for pivotal Phase III clinical trials. The SPA provides the trial sponsors with a binding written agreement that the design and analysis of the study are adequate to support an application submission if the study is performed according to the SPA.
  • Stable disease (SD)
    Treatment outcome in which the disease has not responded to therapy but has not progressed; also refers to disease that initially responded to therapy and remains stable after treatment is stopped.
  • Stage I disease
    Myeloma disease classification based on the Revised International Staging System (R-ISS). Patients with Stage I disease have: ß2-M less than or equal to 3.5mg/L and albumin greater than or equal to 3.5 g/dL, Absence of higher-risk DNA [deletion(17p) and/or translocation t(4;14) and/or translocation t(14;16)], Normal blood levels of lactate dehydrogenase (LDH)
  • Stage II disease
    Myeloma disease classification based on the Revised International Staging System (R-ISS). Patients with Stage II disease have: Neither Stage I nor Stage III disease
  • Stage III disease
    Myeloma disease classification based on the Revised International Staging System (R-ISS) Patients with Stage III disease have: ß2-M greater than or equal to 5.5mg/L and either , Presence of higher-risk DNA abnormalities [deletion(17p) and/or translocation t(4;14) and/or translocation t(14;16)] or High blood levels of LDH
  • Standard-dose chemotherapy
    Administration of chemotherapy at a dose that does not completely destroy the bone marrow; also known asAdministration of chemotherapy at a dose that does not completely destroy the bone marrow; also known as conventional chemotherapy.conventional chemotherapy.
  • Standard of care
    Treatment that is appropriate, accepted, and widely used; also called standard therapy or best practice.
  • Standard risk disease
    Indicates myeloma with an average prognosis.
  • Standard therapy
    Treatment that has been shown to be safe and effective in clinical studies and is adopted as standard practice outside of clinical trials.
  • Stem cell
    Cell that grows and divides to produce red blood cells, white blood cells, or platelets; found inbone marrow and blood.
  • Stem cell transplant
    Therapeutic procedure in which bone marrow or peripheral blood stem cells are collected, stored and infused into a patient following high-dose chemotherapy to restore blood cell production.
  • Stevens-Johnson syndrome
    A rare, but very serious type of rash, resulting from an allergic reaction. It has been rarely documented in patients who received Revlimid. It requires immediate medical attention.
  • Stomatitis
    Mouth sores.
  • Stratification model
    An analytical tool used to sort data, people, and objects into distinct groups.
  • Stringent complete response (sCR)
    A treatment outcome in which there are no detectable abnormal plasma cells in the bone marrow or M protein in the serum or urine and in which a free light chain ratio test is normal.
  • Stromal cell
    Structural cells of the bone marrow that help support and nourish the blood-producing cells.
  • Subcutaneous (SC)
    Administration of a drug under the skin.
  • Subtype
    Molecularly defined type of myeloma; each subtype has unique clinical features and yields distinct disease outcomes.
  • Supplemental New Drug Application (sNDA)
    Compilation of information on the safety and efficacy of a marketed drug that is submitted to the FDA in order to request approval to market the drug for another indication.
  • Supportive care
    Treatment that addresses the symptoms and complications of a disease rather than the disease itself; examples in myeloma include bisphosphonates, growth factors, antibiotics, orthopedic interventions, and pain control measures.
  • Synergistic
    Acts in combination with another agent such that the activity is greater than the simple additive effect of the two agents.
  • Syngeneic stem cell transplant
    Procedure in which bone marrow or peripheral blood stem cells from a patient’s identical twin are collected, stored and infused into the patient following high-dose chemotherapy or radiation therapy.

  • t

  • T cell (or T lymphocyte)
    A type of white blood cell that can be subdivided into two groups, helper and cytotoxic T cells; helper T cells are responsible for adaptive immunity; cytotoxic T cells are killers of cells that have been targeted for death.
  • Tandem transplant
    Type of transplantation technique where a patient receives two planned transplants within a short period of time. Patients may receive 2 autologous transplants or an autologous stem cell transplant followed by a mini-transplant two to four months afterward.
  • Teratogenic
    Relating to or causing birth defects.
  • Thalomid (thalidomide)
    Older oral drug with multiple anti-myeloma effects. Thalomid has been shown to be effective in newly diagnosed and relapsed or refractory myeloma alone and in combination with agents such as dexamethasone. It is chemically similar to  Revlimid®.
  • Thrombocytopenia
    Decrease in the number of platelets (small cell fragments in the blood that help it to clot) in the blood.
  • Time-to-disease progression (TTP)
    A measure of time after a disease is treated until the disease worsens or progresses.
  • Tissue
    A group of structurally and functionally similar cells.
  • Tissue-type plasminogen activator (t-PA)
    Enzyme that helps dissolve blood clots and inhibits angiogenesis.
  • Toxic epidermal necrosis (TEN)
    A rare but life-threatening skin reaction, where skin turns very red and peels off, similar to what you would see with a severe burn. It typically occurs as a side effect to certain drugs but may also appear as a result of infection or suppression of the immune system.
  • Toxic epidermal necrosis (TEN)
    A rare but life-threatening skin reaction, where skin turns very red and peels off, similar to what you would see with a severe burn. It typically occurs as a side effect to certain drugs but may also appear as a result of infection or suppression of the immune system.
  • Toxin
    A poisonous substance.
  • Translocation
    An abnormal change in the DNA where two segments of different chromosomes switch positions.
  • Treatment cycles
    The period in which treatment is given (e.g., 21 days or 28 days). It is usually followed by a rest period in between treatments. 
  • Tumor-induced hypercalcemia (TIH)
    Condition occurring in various forms of cancer noted by elevated levels of calcium in the blood due to increased bone destruction; also known as hypercalcemia of malignancy (HCM).
  • Tumor lysis syndrome
    A condition that can occur during cancer treatment when large numbers of cancer cells die; the breaking up of the cells and release of the material into the blood can cause organ damage.
  • Tumor microenvironment
    The normal cells, molecules and blood vessels that surround and feed a tumor cell. A tumor can change its microenvironment, and the microenvironment can affect how a tumor grows and spreads.
  • Tumor necrosis factor-alpha (TNF-a)
    Cytokine with several effects in myeloma, including promotion of the growth of myeloma cells and activation of osteoclasts.
  • Tumor-specific protein
    Molecule from a tumor cell that can be recognized by the immune system.

  • u

  • Urinalysis
    Test that determines the level of protein and various chemical compounds in the urine.
  • Urine electrophoresis (UEP)
    Test used to detect and measure proteins in the urine, especially Bence-Jones protein; uses an electrical current to separate proteins by their charge.

  • v

  • VAD
    An older type of chemotherapy treatment. It consists of the combination of two chemotherapy drugs (Vincristine, Adriamycin) plus dexamethasone, a steroid.
  • Vascular endothelial growth factor (VEGF)
    One of the major growth factors that promotes the growth of new blood vessels (angiogenesis).
  • Velcade® (also known as bortezomib)
    A highly effective myeloma drug, known as a proteasome inhibitor. It is usually given subcutaneously either alone or in combination with other myeloma drugs.
  • Vertebroplasty
    Procedure used to treat fractures of the spine.
  • Very good partial response (VGPR)
    Treatment outcome in which there is a greater than 90% decrease in M protein.
  • Vincristine
    A type of chemotherapy which is given intravenously (into a vein). It is part of an older type of myeloma treatment. See VAD. 

  • w

  • White blood cell (WBC)
    One of the major cell types in the blood; attacks infection and cancer cells as part of the immune system.

  • z

  • Zofran® (ondansetron)
    A type of medicine used to prevent or treat nausea and vomiting as a result of cancer treatment. It is given either orally or intravenously (into a vein). 
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Myeloma Matters Podcast Series

Podcast Topic Date
ASCT January 17, 2023 View Recording
Clinical Studies November 16, 2022 View Recording
Targeted Immunotherapy August 30, 2022 View Recording
Bone Health June 30, 2022 View Recording View Transcript

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Expert Sessions

Program Chair(s) Date Location of Event
Malin Hultcrantz, MD, PhD
Joshua Richter, MD		 December 20, 2022 Virtual View Recording View Slides Visit Exhibit Hall
Noa Biran, MD
Paul G. Richardson, MD		 June 29, 2022 Virtual View Recording View Transcript & Slides Visit Exhibit Hall

Patient Summits

Program Chair(s) Date Location of Event
Andrzej J. Jakubowiak, MD, PhDv
Benjamin Derman, MD
Monique A. Hartley-Brown, MD, MMSc
Jing Christine Ye, MD, MSc		 September 10, 2022 Chicago, IL (Online & In Person) Register Here
Ravi Vij, M.D., MBA August 20, 2022 St. Louis, MO (Online & In Person) Register Here Visit Exhibit Hall
C. Ola Landgren, M.D., Ph.D.
Joshua Richter, M.D.		 June 18, 2022 Miami, FL (Online & In Person) View Recording View Slides Visit Exhibit Hall
Sagar Lonial, MD
Ajay K. Nooka, MD, MPH		 April 23, 2022 Atlanta, GA
(Online & In Person)		 View Recording View Slides Visit Exhibit Hall
Laura Finn, MD, MS March 19, 2022 Virtual View Recording View Slides Visit Exhibit Hall
Jeffrey Allan Zonder, MD February 19, 2022 Virtual View Recording View Slides Visit Exhibit Hall
Ravi Vij, MD, MBA January 29, 2022 Virtual View Recording View Slides Visit Exhibit Hall
Harsh V. Parmar, MD
David H. Vesole, MD, PhD, FACP		 December 4, 2021 Virtual View Recording View Slides Visit Exhibit Hall
Larry D. Anderson, Jr, MD, PhD
Ankit J. Kansagra, MD		 November 20, 2021 Virtual View Recording View Slides Visit Exhibit Hall

Patient Webinars

Webinar Topic Date      
Multiple Myeloma Precursor Conditions, With Updates Wednesday, April 5, 2023, 2:30 PM-3:30 PM (ET) Register Now Visit Exhibit Hall
BCMA-Targeted Bispecific Antibodies in Multiple Myeloma Tuesday, March 21, 2023, 4:00 PM-5:00 PM (ET) View Recording View Slides
Management of Patients Who Have Relapsed After One to Three Prior Lines of Therapy, With Updates Wednesday, March 8, 2023, 1:00 PM-2:00 PM (ET) View Recording View Slides Visit Exhibit Hall
Focus on Treatments, Monitoring, and Maintenance for Newly Diagnosed Multiple Myeloma Patients, With Updates Friday, February 17, 2023, 12:00 PM-1:00 PM (ET) View Recording View Slides Visit Exhibit Hall
From Diagnosis to Prognosis: Understanding Multiple Myeloma (A Guide for Newly Diagnosed Patients), With Updates   Tuesday, January 24, 2023, 4:00 PM-5:00 PM (ET) View Recording View Slides Visit Exhibit Hall
Treatment Options for Patients Who Have Relapsed After Three or More Lines of Therapy, With an Update on Bispecific Antibodies  Friday, December 2, 2022, 1:00 PM-2:00 PM (ET) View Recording View Slides Visit Exhibit Hall
Multiple Myeloma Precursor Conditions Wednesday, August 17, 2022, 1:00 PM–2:00 PM (ET) View Recording View Slides Visit Exhibit Hall
Management of Patients Who Have Relapsed After One to Three Prior Lines of Therapy Wednesday, July 13, 2022, 2:00 PM–3:00 PM (ET) View Recording View Transcript
View Slides		 Visit Exhibit Hall
Focus on Treatments, Monitoring, and Maintenance for Newly Diagnosed Multiple Myeloma Patients Thursday, June 9, 2022, 2:00-3:00PM View Recording View Transcript & Slides Visit Exhibit Hall
From Diagnosis to Prognosis: Understanding Multiple Myeloma (A Guide for Newly Diagnosed Patients) Tuesday, May 3, 2022, 2:00-3:00PM View Recording View Transcipt & Slides Visit Exhibit Hall
Treatment Options for Patients With Multiple Myeloma Who Have Relapsed After Three or More Lines of Therapy Tuesday, April 5, 2022, 1:00-2:00PM View Recording View Transcript & Slides Visit Exhibit Hall

 

Managing Communication Preferences

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Updates to the Disclosures

Any changes to these Disclosures will be effective upon the earlier of thirty (30) calendar days following our dispatch of an email notice to you or thirty (30) calendar days following our posting of notice of the changes on the Website. These changes will be effective immediately for new users of our Website.

Please note that at all times you are responsible for updating your Personal Data to provide us with your most current email address. In the event that the last email address that you have provided us is not valid, or for any reason is not capable of delivering to you the notice described above, our dispatch of the email containing such notice will nonetheless constitute effective notice of the changes described in the notice.

If you do not wish to permit changes in our use of your Personal Data, you must so notify us prior to the effective date of the changes and discontinue using the Website. Continued use of our Website, following notice of such changes shall indicate your acknowledgement of such changes and agreement to be bound by the terms and conditions of such changes.

Links to Third Party Sites [and Social Media]

Some of our Website may enable users to submit their own content for contests, blogs, videos, and other functions. Please remember that any data you submit or post as user-generated content to the Website become public data. You should exercise caution when deciding to disclose your personal, financial or other data in such submissions or posts. We cannot prevent others from using such data in a manner that may violate these Disclosures, the law, or your personal privacy and safety. We are not responsible for the results of such postings.

Your Rights

  • Upon request, we will provide you with information about whether we hold any of your Personal Data along with any details required to be provided to you under applicable law.  In certain cases, you may also have a right to:
  • rectify any of your Personal Data that is inaccurate;
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  • to request the deletion of your Personal Data, and
  • to obtain a copy of your Personal Data in an easily accessible format.

To submit a request, please contact us as set forth in the Contact Us section below.  We will respond to your request within a reasonable time frame.

You also have the right to withdraw your consent to our processing of your Personal Data, when our processing is solely based on your consent. You can do this by discontinuing use of the Website, including by closing all of your online accounts with us and contacting us as set forth in the Contact Us section below to request that your Personal Data be deleted.  If you withdraw your consent to the use or sharing of your Personal Data for the purposes set out in these Disclosures, you may not have access to all (or any) of the Website, and we might not be able to provide you all (or any) of the Website. Please note that, in certain cases, we may continue to process your Personal Data after you have withdrawn consent and requested that we delete your Personal Data, if we have a legal basis to do so.  For example, we may retain certain information if we need to do so to comply with an independent legal obligation, or if it is necessary to do so to pursue our legitimate interest in keeping the Website safe and secure.

If you have any complaints regarding our privacy practices, you have the right to lodge a complaint with your national data protection authority (i.e., supervisory authority).

International Data Transfers

Adequacy Decision:  We may transfer your Personal Data to Switzerland and other countries which the European Commission has approved as providing adequate protection to personal data.  A list of these countries can be found here:

Standard Contractual Clauses:  The European Commission has adopted standard data protection clauses, which provide safeguards for personal data transferred outside of the EEA. We sometimes use Standard Contractual Clauses when transferring Personal Data from a country in the EEA to a country outside the EEA. You can request a copy of our Standard Contractual Clauses by contacting us as set forth in the Contact Us section below.

With your consent:  In respect of certain cross-border personal data transfers, such as in research studies that you provide consent to enter, we will obtain your consent to transfer your Personal Data outside the EEA after first informing you about the possible risks of such a transfer.

By contract:  We will transfer your Personal Data outside the EEA if the transfer is necessary to the performance of a contract between you and MMRF, or if the transfer is necessary to the performance of a contract between MMRF and a third party, and the contract was entered into in your interest.

In addition, we may transfer your Personal Data outside the EEA if the transfer is necessary to establish, exercise or defend legal claims or to protect your vital interests.  



Revised International Staging System (R-ISS) Criteria

Stage Criteria
I ß2-M less than or equal to 3.5mg/L and albumin greater than or equal to 3.5 g/dL
Absence of higher-risk DNA abnormalities
Normal lactate dehydrogenase (LDH)
II Not Stage I or III
III ß2-M greater than or equal to 5.5mg/L and either
Presence of higher-risk DNA abnormalities or
High LDH
ß2-M = beta2-microglobulin
Higher-risk DNA abnormalities include del(17p) and/or translocation (t4;14) and/or translocation (14;16)
LDH = lactate dehydrogenase

Measuring your prognosis

Test Indication Values Indicating a More Favorable Prognosis
Beta 2-microglobulin (β2-microglobulin or β2-M) Higher levels reflect more extensive disease and poor kidney function. <3.5 mg/mL
Albumin level Higher levels may indicate better prognosis. ≥3.5 g/dL
Lactate dehydrogenase (LDH) level Higher levels indicate more extensive disease. Age ≤60yrs.: 100-190 U/L
Age >60yrs.: 110-210 U/L
Freelite® serum free light chain assay Abnormal results may indicate poor prognosis (also indicates risk of progression of MGUS or asymptomatic myeloma to symptomatic myeloma). Free light chain ratio MGUS: 0.26-1.65
Asymptomatic myeloma: 0.125-8.0
Symptomatic myeloma: 0.03-32
Chromosome analysis (cytogenetic testing by either karyotyping or FISH) Presence of specific abnormalities may indicate poor prognosis. Absence of abnormalities
Gene expression profiling Presence of specific group of genes can predict low or high risk of early relapse. Personalize risk score

Patient Webinar

Webinar Topic Date
Learn Your Labs Tuesday, February 4, 2020 1:00PM ET View Recording View Slides
Supportive Care Wednesday, March 4, 2020 1:00PM ET View Recording View Slides
Smoldering Myeloma Thursday, April 23, 2020 1:00PM EDT View Recording

Accredited activities

View Activity

Topic Date Link
Putting the CAR(T) Before the Horse: Practicalities of T Cell–Activating Therapies in Multiple Myeloma Expires: January 25, 2024 Learn More
Applying the Latest Clinical Data in Multiple Myeloma Patient Care in the Community Setting (Internal Medicine) Expires: January 26, 2024 View Slides
Applying the Latest Clinical Data in Multiple Myeloma Patient Care in the Community Setting (Oncology) Expires: December 1, 2023 Learn More
What’s My (Next) Line? Treating Relapsed/Refractory Multiple Myeloma When Three Prior Treatment Lines Fail Expires: September 30, 2023 Learn More
Myeloma Masters: The Ultimate Myeloma Patient Care Quiz Show Expires: April 27, 2023 Learn More
Ace the Case: Worsening Fatigue and Diarrhea in a 64-Year-Old Woman With IgA Lambda Multiple Myeloma Expires: March 23, 2023 Learn More
Ace the Case: 71-Year-Old Woman With IgG Lambda Multiple Myeloma at Third Relapse Expires: March 9, 2023 Learn More

Patient toolkit

Program Chair(s) Date Location of Event Access Link
Program Chair Robert Z. Orlowski MD, PhD Elisabeth E. Manansanch, MD May 21, 2020 Virtual View Recording View Slides

Patient toolkit

Title Download Links
Managing Myeloma Resource Brochure English Spanish
Multiple Myeloma Disease Overview English Spanish
Multiple Myeloma Treatment Overview English Spanish
Multiple Myeloma Caregiver Guide English Spanish
Precision Medicine Brochure English Spanish
Immunotherapy English Spanish
Autologous Stem Cell Transplantation English
Myeloma Precursor Conditions English

Register to speak to a myeloma mentor



Let’s connect

Contact the MMRF with any questions or comments—whether you are a patient, caregiver, researcher or clinician, we are always glad to hear from you.



By filling out this form you are agreeing to receiving MMRF communications. You may unsubscribe at any time via your email.

Revised International Staging System for multiple myeloma

Stage Criteria
I ß2-M<3.5mg/L and albumin ≥3.5 g/dL and Absence of high-risk DNA abnormalitiesaand Normal lactate dehydrogenase (LDH)
I Not Stage I or III
III ß2-M≥5.5mg/L and
Presence of high-risk DNA abnormalitiesaor
High LDH
ß2-M = beta2-microglobulin
aHigh-risk DNA abnormalities include del(17p) and/or translocation t(4;14) and/or translocation t(14;16)

Measuring your prognosis

Test Indication Values Indicating a More Favorable Prognosis
Beta 2-microglobulin
(β2-microglobulin or β2-M)		 Higher levels reflect more extensive disease and poor kidney function <3 mg/mL
Albumin level Higher levels may indicate better prognosis ≥3.5 g/dL
Lactate dehydrogenase (LDH) level Higher levels indicate more extensive disease Age ≤60yrs.: 100-190 U/L
Age >60yrs.: 110-210 U/L
Albumin level Higher levels may indicate better prognosis ≥3.5 g/dL
FreeliteTM serum free light chain assay Abnormal results may indicate poor prognosis (also indicates risk of progression of MGUS or asymptomatic myeloma or symptomatic myeloma Free light chain ratio MGUS: 0.26-1.65
Asymptomatic myeloma:0.125-8.0
Symptomatic myeloma:0.03-32

High Impact Topics Videos

High impact topic videos, or HITs, are videos that use engaging animations and narration to present information on topics of importance to myeloma patients and their caregivers. Presented in a patient-friendly manner and viewable on iPads, tablets, and smartphones, these HITs bring to life and explain concepts that can sometimes be difficult for patients and caregivers to understand.

The MMRF wishes to thank the following reviewers and contributors to these HITs: Craig Emmitt Cole, MD; Faith E. Davies, MBBCh, MRCP, MD, FRCPath; Marc Davis; Irene Ghobrial, MD; Colin Todd Kennedy; Amrita Y. Krishnan, MD; Ola Landgren, MD, PhD; Louise Miller Lavin, BSN, MSN, LPCC; Joshua Richter, MD; Nina Shah, MD.

Title Description
MRD (Minimal residual disease) Learn what MRD is, how it is measured, and what it might mean if your doctor tells you that you are MRD positive or MRD negative.
Immunotherapy Understand how your immune system interacts with your myeloma, and how new immunotherapies are helping patients’ immune systems recognize and destroy myeloma cells.
Genomics Hear how doctors can use genomic information from your myeloma cells to provide therapy that is tailored to your myeloma subtype.
Learn Your Labs This video provides information on laboratory tests that myeloma patients may undergo. Learn about why and how the tests are done and what the results mean.
Autologous Stem Cell Transplantation (ACST) Learn the risks and benefits of ACST, a key part of a personalized treatment plan for many myeloma patients.
Clinical Trials Discover how clinical trials work.
Multiple Myeloma Precursor Conditions Find out the difference between monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) and what factors may put individuals with these conditions at higher risk for progressing to multiple myeloma.
MMRF's The Right Track(TM) Program This HIT shows patients who have been diagnosed with multiple myeloma how to get on the right treatment path to their best outcome as quickly as possible.

 

Meet Coach Salim Martin, M.Ed

  • Onyx Multisport, a New York City based fitness company
  • USAT-certified Triathlon and Cycling coach
  • Providing training tips and support

 

Toni Abraham - Sr. Manager, Events & Partnerships

  • Fueled by being in service to others
  • Favorite Quote: The ones who are crazy enough to think they can change the world, are the ones who do. -Steve Jobs
  • NY Mets & NY Giants Fanatic
  • Best Aunt in the World Award Winner given by L&K

Tia Dawson - Sr. Associate, Events & Partnerships

  • Dog Lover:Please bring your furry friends to the walks and make sure to say hello
  • Best Fundraising Tip: Personalize your fundraising page and outreach. People want to feel like their money is meaningful and will make a real impact.
  • Avid Sports Fan:Let’s go Bruins and Pats!

 

Meet Lauren Charamut

  • Title: Associate Director, Events and Partnership
  • Biked: Bryce to Zion with the Road to Victories 2018 Team
  • Favorite Mid-Ride Snack: Stroopwafel
  • Favorite Part of Cycling: The uphill climb

 

Meet Lauren Charamut

  • Title: Associate Director, Events and Partnership
  • Hiked: Mt. Democrat, Mt. Fuji, Havasu Falls (Grand Canyon), Patagonia, Mt. Washington (countless times)
  • Favorite Trail Snack: Stroopwafel
  • Best Training Advice: “Keep your boots in the sun”



 

Meet Brianne:

  • Senior Associate, Events and Partnerships
  • Favorite 5K Fundraising Tip: Make your ask in several different ways (in person, on Facebook, by email, etc.!)
  • Cheer Squad: My boyfriend, parents, two brothers and best friends.

Contact Me

 

Meet Ashley:

  • Manager, Events and Partnerships
  • 1 year with the MMRF Walk/Run Team
  • Favorite 5K Fundraising Tip: Set a goal and break it down for your supporters (Example: If 20 people donate $25 I’ll reach my goal of $500 towards a cure!).
  • Cheer Squad:  My parents, sister and local community.

Contact Me

 

Meet Ed:

  • Race Manager, MMRF Team for Cures 5K Walk/Run Program
  • 3 years with the MMRF Walk/Run Team
  • Favorite 5K Fundraising Tip: Take advantage of the power of social media.
  • Cheer Squad: My family. (Father: Ed, Mother: Susan, Sister: Kiera) And my super supportive girlfriend, Elyse.

Contact Me

 

Meet Jane:

  • Director, Events & Partnerships
  • 13 years with the MMRF Endurance Team, and 3 years with the MMRF Walk/Run Team
  • Favorite 5K Fundraising Tip: Cast a wide net. You never know who will surprise you.
  • Cheer Squad: My husband Michael and 3 grown kids.

Contact Me



 

Meet Lauren Bruce

  • Associate Manager, Events and Partnerships
  • Newest member of the MMRF Team for Cures staff
  • 8-time Marathon Finisher (4x Chicago, Rock N Roll Raleigh, Marine Corps Marathon duo team, and DIY duo team in 2020), 30+ Half Marathon finishes
  • Favorite Race Day Tip: Wear more sunscreen and body glide than you think you need!
  • Marathon Mantra: Yes, you can!
  • Cheer Squad: Her 2 cats and running partner, Ethan

 

Meet Jane

  • Director, Events & Partnerships
  • 13 years with the MMRF Endurance Team
  • 8-time Marathon Finisher (Chicago, Boston 2X, Disney, National, Philly 2X, Mystic)
  • Favorite Race Day Tip: You will not sleep well the night before your marathon, so don’t sweat it! Hoard sleep leading up to race weekend
  • Marathon Mantra: You did your homework. You’ve got this!
  • Cheer Squad: Husband and 3 grown kids

Contact Me

Leadership and Corporate Connections

For further inquiries on leadership and our strategic plan please fill out the below information. Once submitted, a member of our team will contact you as soon as possible.

Company Website:
Total Employees:
Annual Revenue:
Is your organization a 501(c)(3)?:
Is there a written strategic plan?:
Have you read the Playbook?:


Facebook Live Events

Faculty Date Event Topic
Jesus Berdeja, MD
Sham Mailankody, MBBS		 January 6, 2023 FAQs From the 2022 American Society of Hematology Annual Meeting View Recording
Nitya Nathwani, MD
Jennifer Bautista, NP		 December 15, 2022 FAQs on Multiple Myeloma Following Relapse View Recording
Ola Landgren, MD
Dennis Verducci, MSN, RN, NP-BC, OCN		 September 7, 2022 MM Precursor Conditions View Recording
Andrew Yee, MD
Stephanie Sanford, NP		 July 28, 2022 MM Following Relapse After 1-3 Prior Lines of Therapy View Recording View Transcript
Ravi Vij, MD
Angela Vickroy, NP		 July 20, 2022 FAQs From the American Society of Clinical Oncology Annual Meeting View Recording
Sergio Giralt, MD
Emily Patterson, NP		 June 29, 2022 Treatments, Monitoring, and Maintenance for Newly Diagnosed Patients View Recording View Transcript
Ken Shain, MD, PhD
Christine Simonelli, BSN, RN, OCN		 May 24, 2022 MM Diagnosis and Prognosis View Recording View Transcript
Sandy Wong, MD
Donna D. Catamero, ANP-BC, OCN, CCRC		 April 14, 2022 MM Following Relapse After 3 or More Lines of Therapy View Recording View Transcript
Craig E. Cole, MD,
Amy Pierre, RN, MSN, ANP-BC		 October 25, 2021 MM Precursor Conditions in the Black Community View Recording






Grace Allison

RN, BSN, OCN, RN-BC – Patient Navigation Center

Grace has been a registered nurse for more than 30 years. She spent the last 28 years working at one of the largest myeloma programs in the U.S., the University of Arkansas for Medical Sciences (UAMS). She was fortunate to have spent her career at UAMS under the tutelage of one of the most well known myeloma physicians, Dr. Bart Barlogie. She received her nursing education in Ireland, and completed a bachelor’s of nursing degree at the University of Arkansas. She is a member of the Oncology Nursing Society and a nationally Oncology Certified Nurse. She is also a board certified medical-surgical registered nurse (RN-BC). She started at the MMRF in Summer of 2020.

Brittany Hartmann

RN, BSN – Patient Navigation Center

Brittany Hartmann, RN, joins the MMRF as a Nurse in the Patient Navigation Center. Brittany worked as a Myeloma Clinical Coordinator in a high-volume call center at the Ruttenberg Treatment Center at Mount Sinai Hospital in New York City for the past 5 years. Here, she supports myeloma patients in a variety of ways from triaging calls, to educating patients on their myeloma, labs and test results, and coordinating with research and management to implement integral changed and streamline processes for access to new treatments. Prior to Mount Sinai, she worked as an Oncology nurse at Saint Barnabas Medical Center in New Jersey. Brittany earned her Bachelor of Science in Nursing at the University of Delaware, where she had the opportunity to be a student nurse for a private physician for over a year.

Candice Del Rio

Candice Del Rio

MS, BSN, BA, RN – Manager, Patient Navigation Center

Candice Del Rio is the Manager of the Patient Navigation Center at the MMRF. She is responsible for overseeing the daily operations of the PNC and guiding myeloma patients through their disease journey. She most recently worked at the Massachusetts General Hospital for over 11 years as a Staff Nurse in the inpatient Hematology/Oncology unit and as a Clinical Research Nurse in the Bone Marrow Transplant Department. Prior to her career in nursing, she worked in marketing and advertising in the real estate industry for 4 years. She earned a BA degree in Communications with a concentration in Sociology from Boston College and completed her nursing education with BSN and MS degrees from Northeastern University.

 

Adrian Rosenkranz

Chief Operating Officer
Salesforce Essentials

Adrian Rosenkranz, a Multiple Myeloma caregiver, is the COO of Salesforce Essentials; in that role he’s responsible for steering the company’s operations, vision, and customer experience. With over a decade of experience in enterprise software, Adrian is widely respected for being a boots-on-the-ground leader with a track record of driving growth. Prior to his current position, Adrian held roles at Salesforce in Sales Strategy & Ops, Sales, and Corporate Marketing, giving him valuable experience in multiple revenue functions.  

Adrian serves on the board of the Stanford Athletics Buck/Cardinal Club, which supports all varsity sports at Stanford University. He has also served as an advisor for Harvard Business School's Kraft Precision Medicine program, using his experience with direct-to-consumer teams to help nonprofits accelerate precision medicine efforts via direct-to-patient engagement. 

Adrian earned his BS from Stanford University, where he also served as the kicker for the Stanford football team under Coach Jim Harbaugh. He currently lives in San Francisco, where he loves to exercise and explore the outdoors. 

 

Rob Miani - Chief Financial Officer

Rob Miani joined the MMRF team as Chief Financial Officer in 2016. Most recently he was the Vice President of Finance and Corporate Controller of Aptuit, LLC, a global contract research organization providing integrated early discovery to mid-phase drug development services in the pharmaceutical industry. Rob has over 20 years of leadership experience in the private and public sectors, holding managerial positions in the renewable energy, private equity, Internet and technology industries, including Davenport Newberry, Oak Investment Partners and INT Media Group. He began his career with Arthur Anderson LLP in the Assurance and Business Advisory Services Division. Rob is a CPA and received his BS degree in Accounting from Fairfield University.

Mike Mortimer

Managing Partner and Founder
GHO Capital

Chairman of the Board
MMRF

Mike is an experienced healthcare industry senior executive who brings a 30+ years track record in operational and management positions.

In his former role as an Executive Vice President in the core leadership team at Quintiles (now IQVIA), Mike was instrumental to driving the international growth of a now leading global Clinical Research Organisation. Prior to Quintiles, Mike was a Senior Vice President at Charles Schwab, responsible for the global retail and internet organizations.

Mike currently sits on the boards of Envision, X-Chem, Ardena, BioAgilytix, Validant and Alcaliber and has overseen successful exits from Quotient Sciences and Caprion Biosciences.

Originally from the US and holding a bachelor’s degree in Behavioural Sciences from the Ohio State University, Mike has worked and lived across the USA, UK and Asia.

Paul Giusti

President
Riverwoods Holdings, LLC

Paul Giusti is the former President and Chief Executive Officer of the Multiple Myeloma Research Foundation (MMRF). Prior to the MMRF, Mr. Giusti worked as a Chief Executive Officer, leader, executive and entrepreneur for over 30 years; he has founded, managed and led a variety of businesses. Early in his career, Mr. Giusti worked as an executive for GE where he held a number of management positions with a wide range of responsibilities.

Mr. Giusti has worked closely with the MMRF since its founding in 1998. In addition to chairing the successful $100 million capital campaign, he has served as a consultant for a number of foundation projects, led several MMRF outreach efforts and spoken on behalf of the MMRF.

Mr. Giusti holds a Bachelor of Science degree from the Colorado School of Mines and an MBA from Harvard University.

Kathy Giusti

Founder and Chief Mission Officer
MMRF and MMRC

Faculty Co-Chair, HBS Kraft Precision Medicine Accelerator
Harvard Business School

Kathy Giusti, a multiple myeloma patient, is the Founder of the Multiple Myeloma Research Foundation (MMRF) and the Multiple Myeloma Research Consortium (MMRC). She is also the Chief Mission Officer of the MMRF. Kathy is the Henry & Allison McCance Family Senior Fellow at Harvard Business School, where she serves as Faculty Co-Chair of the HBS Kraft Precision Medicine Accelerator. Kathy has more than two decades of experience in the pharmaceutical industry, previously holding senior positions at G.D. Searle and Merck.

Since founding the MMRF in 1998, Kathy has become a widely respected leader in establishing innovative, collaborative research models in the areas of tissue banking, genomics, and clinical trials. These models are dramatically accelerating the pace at which lifesaving treatments are brought to patients and are building an end-to-end solution in precision medicine. Today, she is recognized as a pioneer of precision medicine, a champion of data sharing, and a strong advocate for patient engagement.

In 2016, Kathy was named Faculty Co-Chair of the Harvard Business School (HBS) Kraft Precision Medicine Accelerator, a $20 million program endowed by Robert Kraft and the Kraft Family Foundation. Under her leadership, the HBS Kraft Precision Medicine Accelerator convenes best-in-class leaders from science, business, and technology to identify and solve challenges slowing the advancement of precision medicine. The HBS Kraft PM Accelerator disseminates best practices and models to overcome these challenges, and ultimately enables faster adoption of high-impact innovations.

Kathy has earned numerous prestigious awards and recognitions, including being named 1 of 3 Top Business Leaders Disrupting Medicine by Fortune Magazine and #19 on Fortune’s World’s 50 Greatest Leaders list. She was also named one of the world’s 100 Most Influential People by TIME magazine. Kathy received the Open Science Champion of Change award by the White House. In addition, she has been honored with the American Association for Cancer Research Centennial Medal for Distinguished Public Service and the Healthcare Businesswomen’s Association’s Woman of the Year Award.

Kathy serves on the advisory boards of Verily and Verily’s Project Baseline and is a member of the Harvard Business School (HBS) Health Advisory Board. She a Member of the FasterCures Non-Profit Council. Kathy previously served on President Obama’s 2015 Precision Medicine Initiative Working Group, the President’s Council of Advisors on Science and Technology (PCAST), National Cancer Advisory Board (NCAB), and the National Cancer Policy Board (NCBP).

Kathy has been featured on the Today Show, NBC Nightly News, CBS Evening News, Fox News, CNN, and Bloomberg. Her efforts have also been profiled by Fortune, The Wall Street Journal, Harvard Business Review, The New York Times, Forbes, The New Yorker, WIRED, and Fast Company.

Kathy received her MBA in general management from Harvard Business School and holds an honorary Doctorate from the University of Vermont.

Learn more about Kathy.

Sarah Coulter

RN, OCN

Sarah has been a registered nurse for the past five years, specializing in Hematology Oncology and Bone Marrow Transplant. She has spent over ten years in the Oncology field and started her career at Yale New Haven Hospital. Over the last three years, Sarah worked as a traveling nurse in California, South Carolina, Florida, Texas and Maryland. She earned her nursing degree from St. Vincent’s School of Nursing. She is chemotherapy certified and is currently in school to obtain her master’s degree in nursing education.

 

Erin Mensching

RN, BSN, BA, OCN – Patient Navigation Center

Manager

Erin is the Manager of the Patient Navigation Center. She is passionate about helping to guide myeloma patients and to further research for the myeloma community. She has been a registered oncology nurse for eleven years. She served on the Patient Council Committee at the Norwalk Hospital and is a member of the Oncology Nursing Society. Erin is a graduate of Fairfield University’s School of Nursing and earned her bachelor’s degree in psychology from the University of North Caroline at Chapel Hill. Prior to becoming an oncology nurse, Erin was a healthcare representative for Pfizer and Sanofi-Aventis.

 

Christopher Williams - Vice President of Business Development

 Christopher Williams was named Vice President of Business Development at the MMRF in 2017, responsible for business development, partnership and joint venture efforts for the foundation. He is a business development leader with a strong scientific background, specializing in the pharmaceutical and diagnostics space. Most recently he served as the VP of Business Development at WaveSense where he was in charge of their US commercialization strategy and product expansion, as well as being responsible for overseeing their strategic partner relationships.

Previously Chris was VP of Business Development at SkylineDx, providing commercialization strategy for their oncology portfolio. With PerkinElmer, as the Market Segment Leader in Oncology, he had responsibility for their cancer diagnostic products including strategy, launch activities, external presentations and marketing execution.

While at Millennium Pharmaceuticals, Chris held roles in the Protein Science, Technology Development and Proteomics groups. He also had scientific roles at Schering-Plough and the Sandoz Research Institute.

Chris holds graduate and post-graduate degrees in Microbiology/Molecular Biology and Protein Biochemistry from Clemson University. 

Steve Varley - Vice President, Development

Steve Varley joined the MMRF team in 2018 and is responsible for the fundraising efforts of the organization. Most recently he served as Associate Dean for Advancement at Yale University, leading the fundraising efforts for Yale School of Nursing. Previously he worked as the Vice President for Advancement at Gardner-Webb University where he organized and successfully executed the University’s most recent capital campaign. Steve received a BS degree from Chowan University and holds an MBA from Gardner-Webb University.

Laura Gilman - Vice President of Events

Laura Gilman is the Vice President of Events at the MMRF where she manages the entire events portfolio. Prior to joining the MMRF in 2010 Ms. Gilman was the Vice President of Citigroup’s Investment Research Conferences where she directed the design and execution of the bank’s high profile research conferences and events. Before joining Citigroup, Ms. Gilman was the Director of Meetings, Client Relations and Incentives at Victoria’s Secret Beauty. She began her career at Morgan Stanley managing the bank’s IPO Roadshows. Ms. Gilman has over 20 years of experience designing and executing events and initiatives that generate revenue. She received her B.A. in English Literature from the Catholic University of America and lives in Westport, CT with her husband and son.

Karen Dietz, JD, MBA - Chief Administrative Officer and General Counsel

 

Karen Dietz, JD, MBA, is the Chief Administrative Officer and General Counsel. Karen is responsible for overseeing the Legal and Human Resource Departments, corporate governance, compliance, contributes to strategic planning, oversees planning and execution of the organization’s operating plans, and collaborates with other disease foundations to share insights from MMRF success.

Additionally, Karen has concentrated efforts on optimizing the governance structure of the MMRF’s subsidiary companies: Myeloma Investment Fund (MIF) and the Multiple Myeloma Research Consortium (MMRC). Karen has worked with the consortium sites and pharma companies to launch nearly 100 multi-center clinical trials including the first-ever myeloma platform trial, MyDRUG.

Prior to joining the MMRF in 2007, Karen worked as In-House Counsel at Océ Imagistics North America a subsidiary of Canon Printers, was the Legal Counsel for the United States Junior Chamber of Commerce, and worked at the Law Firm of Attorney Raymond Lubus, Corporate Payroll Services, Orion Mobility, and Praxair.

Karen earned her Doctorate of Jurisprudence and her Masters of Business Administration from Western New England University. Karen earned her Bachelor of Science in Justice and Law Administration from Western Connecticut State University.

 

 

 

 

 

 

Anne Quinn Young, MPH - Chief Marketing and Development Officer

Anne Quinn Young, MPH, is the Chief Marketing and Development Officer at the MMRF and is responsible for overseeing the strategy and execution of the organization’s marketing, communications, patient engagement, and fundraising efforts in support of the organization’s mission to accelerate precision medicine and a cure for every patient.  

Anne has been named to the PharmaVoice 100, and represents the MMRF on a number of working groups and committees including the Direct-to-Patient (DTP) solutions team at the Harvard Business School (HBS) Kraft Precision Medicine Accelerator and the Cancer Support Community Frankly Speaking About Cancer: Multiple Myeloma National Advisory Board. She has co-authored a number of peer-reviewed abstracts and publications on the MMRF Precision Medicine Model and identifying knowledge gaps and opportunities to improve patient empowerment and engagement in optimizing their own outcomes.

Prior to joining the MMRF in 2002, she was a consultant in the Healthcare Practice of Datamonitor, a global market research and business intelligence company. She previously worked in healthcare public relations at Burson-Marsteller and the Chandler Chicco Agency, following a postgraduate internship at the Department of Justice, Antitrust Division. Anne has a Masters of Public Health from the Mailman School of Public Health of Columbia University and graduated cum laude from Dartmouth College with a Bachelor of Arts in Government.

 

 

Lori Tauber Marcus

Founder
Courtyard Connections

Vice Chairman of the Board
MMRF

Lori Marcus is an independent board director and keynote speaker. She is currently serving in the role of Vice Chairman of the MMRF board. Lori is also the Chairman of the board of DNA Diagnostics Center, a growing leader in private DNA testing services, where she guides overall strategy and governance for corporate growth. Additionally, she is an independent Board Director for SHARE, a 40-year-old survivor-led organization based in New York City that provides support, information, and resources to women affected by breast and ovarian cancers. Lori also currently serves on the CMO advisory board for VentureBeat and is a board advisor to Carrington Farms.

Most recently, Ms. Marcus served as Interim Global Chief Marketing Officer for Peloton Interactive, Inc., a private equity and venture capital backed home fitness innovator. At Peloton, Lori drove business growth with strategy, brand marketing, communications, PR, social/digital media, consumer insights, data analytics, creative services, and community engagement. Prior, Lori was Chief Global Brand and Product Officer at Keurig Green Mountain. With more than 30 years of broad-based marketing and general management experience, Lori was responsible for global brand and product management for the Keurig system of innovative brewers and beverages. During her tenure at Keurig Green Mountain, she also led the company’s global marketing efforts and all aspects of e-commerce, digital/social media, marketing insights, and graphic design. Lori was also Chief Marketing Officer of The Children’s Place Retail Stores and SVP Marketing at PepsiCo.

Lori is a graduate of the Wharton School, University of Pennsylvania.

Steven Labkoff, MD, FACP, FACMI - Chief Data Officer 

Dr. Steven Labkoff is the Chief Data Officer at the Multiple Myeloma Research Foundation. Dr. Labkoff is a global medical leader with a track record of developing cutting edge strategies towards new healthcare delivery models. He has demonstrated success in the convergence of medicine, life sciences and policy across disparate organizations including government, non-government organizations (NGOs), health plans and academic institutions. He joined the MMRF after a 25-year career in healthcare informatics for the Life Science Industry where he worked on a wide array of issues ranging from the secondary uses of healthcare data for Life Sciences, health information technology policy, Big Data and analytics and medical affairs. He was most recently Executive Director, Medical Strategy at Purdue Pharma. In that role he led Purdue’s Big Data initiative as well as medical strategy for both pipeline and inline products. Prior to Purdue he was Vice President of Life Sciences at Intelligent Medical Objects focused on leveraging medical vocabularies, ontologies, and terminologies for Life Science customers.

From 2011-2014 he was Executive Director, R&D Informatics and Head of Strategic Programs in AstraZeneca’s Research & Development Information Department where he led groups on Real World Evidence and Payer Evidence, Personalized Medicine and Biomarkers and Clinical Trials Design and Interpretation, dedicated to leveraging healthcare data for the development of ethical pharmaceuticals.

Previously, Dr. Labkoff was an instructor of Medicine and Medical Informatics at Brigham and Women’s Hospital, Harvard Medical School. He completed a post-doctoral fellowship at Harvard Medical School and Massachusetts Institute of Technology in Medical Informatics where he focused on the uses of point-of-care computing and mHealth. He did his cardiology training at the University for Medicine and Dentistry of New Jersey, his medical training at the University of Pittsburgh and at the Albert Einstein Medical Center in Philadelphia. He is a Fellow of the American College of Physicians and the American College of Medical Informatics, and an executive board member of the American Medical Informatics Association.

 

Hearn Jay Cho, MD, PhD - Chief Medical Officer 

Hearn Jay Cho, MD, PhD joined the MMRF as Chief Medical Officer (CMO). Dr. Cho is responsible for developing the MMRF’s clinical research strategy and accelerating drug development programs as well as for leading the Multiple Myeloma Research Consortium (MMRC), a group of 25 leading research centers dedicated to researching and advancing treatment options for multiple myeloma patients.

Hearn Jay Cho is an Associate Professor of Medicine at the Icahn School of Medicine at Mt. Sinai and an Attending Physician with the Multiple Myeloma Service at the Mt. Sinai Tisch Cancer Institute. Dr. Cho’s laboratory is investigating novel therapies for multiple myeloma in two areas.

First, they are investigating immunologic therapies with a focus on using cutting edge genomic and immunologic assays to map the interaction between myeloma and the immune system in the tumor microenvironment. These projects illuminate the mechanisms of action of novel immune therapies in both laboratory models and clinical trials and will inform the design of rational combinations. This program has a special focus on immunologic therapy in the setting of autologous stem cell transplantation for myeloma.

Second, Dr. Cho’s group discovered that two of the type I Melanoma Antigen GEnes (MAGE), MAGE-A3 and MAGE-C1, are commonly expressed in multiple myeloma and are correlated with progression of disease and proliferation. They demonstrated that type I MAGE plays a critical role in conferring resistance to chemotherapy and inhibition of apoptosis in myeloma cells through regulation of Bcl-2 family proteins and the tumor suppressor p53. Dr. Cho’s group is conducting biochemical and structural studies to identify novel pharmacologic strategies for inhibition of type I MAGE activity in myeloma.

 

 

Randi S.Randi S

51, from Fort Lauderdale, FL
Initially Diagnosed: 2016
Current Diagnosis: Relapsed, Refractory
Treatment Received: SCT, Cytoxan, Revlimid, Velcade

Upon Randi’s diagnosis, she conducted an abundance of research and tried to keep an optimistic mindset. She decided to pursue the treatment plan that had a more holistic approach, and if it came to a point in which she needed a transplant, she wanted to pick the environment that felt the most nurturing. Randi knew that there were many steps and lifestyle changes that she had to make towards her healing. Her diagnosis affected her in medicinal, environmental, holistic, mental, personal and spiritual ways. She continues to maintain her super healthy lifestyle and practices good dietary habits. It was difficult for Randi to believe that she had cancer, as she had to learn to recreate herself and was grateful to be alive. Randi is very active in the multiple myeloma community and participates in races all over the country. She told her doctors that she was willing to do her homework to propose to them ways in which she could slowly return to participating (to a certain degree) in some of her active hobbies and most importantly, she has learned to listen to her body.

Evelyn H.

62, from the Houston, TX area
Initially Diagnosed: 2014
Current Diagnosis: recently completed 2nd Autologous Stem Cell Transplant
Treatments Received: bortezomib, dexamethasone, lenalidomide , carfilzomib , daratumumab, and pomalidomide

Evelyn has been living with MM for almost nine years.  What she has learned from this was to expect the unexpected.  She had her first relapse in January of 2021, which was unexpected.  After completing treatment she was back into a complete response.  What she has found helpful to persevere along the journey was a strong support team – in healthcare, spiritual aspects, family and circle of friends.  She believes it’s imperative to have the entire team working in tandem.  Developing short term and long term treatment plans with her healthcare team, and allowing room for adjustment as needed has been a part of process.  Evelyn looks forward to helping others navigate their unexpected.

Tricia C.Tricia C

59, from Rocky Hill, CT
Initially Diagnosed: 2014
Current Diagnosis: In Remission
Treatment Received: SCT, RVD, IVIG, Clinical Trial Participant

In 2005, Tricia was dealing with extreme fatigue. Her primary care physician ordered routine bloodwork and found that she was severely anemic. She was then sent to a local hematologist who did a bone marrow biopsy. At this time she was diagnosed with smoldering myeloma after receiving a second opinion. It wasn’t until 2014 that she was diagnosed with active Multiple Myeloma. Tricia participates in MMRF events in hopes of furthering multiple myeloma research. She enjoys sharing her personal experience with other myeloma patients and is looking forward to helping others understand this disease better and find resources for them that will help with their personal myeloma journey.

Lisa B.

37, Trumbull, CT
Initially Diagnosed: MGUS 28, MM 30
Current Diagnosis: Multiple Myeloma-stable
Treatment Received: Revlimid, Velcade, Dex, Autologous SCT, Pomalyst, Carfilzomib @ MSK in NY

Lisa was diagnosed with MGUS at age 28  -  discovered during a routine physical exam showing high protein levels in her bloodwork, but she was otherwise asymptomatic. After 18 months,  MGUS developed into MM, requiring immediate treatment at age 30. Dealing with cancer at such a young age was shocking, challenging and unrelatable/lonely, but with a strong support system, cancer mentors, great doctors/treatment, The MMRF, a positive outlook, education, faith and perseverance she reached complete remission after transplant and lived a very 'new normal' life, still able to balance career, life, and her condition.  Lisa relapsed after about 5 years, but her condition is currently stable. Lisa wants to help other cancer patients by mentoring, sharing experiences,  and offering resources, but most importantly helping them realize they are not alone.

Ethan H.Ethan H

28, from Worcester, MA
Initially Diagnosed: 2013
Current Diagnosis: In Remission, Multiple myeloma with solitary plasmacytoma
Treatment Received: Radiation, Bone replacement, SCT, VRD, Ninlaroe

I was diagnosed with multiple myeloma seven years ago at the age of 22. It started with pain in my hip that was quickly diagnosed as cancer. I understand the disruption to “normalcy” that a multiple myeloma diagnosis may have caused for you. I’ve made it my mission to make a difference for others dealing with this disease. This time period can be filled with uncertainty, but the thing that has always helped, whether it was the day of the diagnosis or currently, is the importance of having people in your life that are there for you.

Casey Joe W.Casey Joe W

36, from Acworth, GA
Initially Diagnosed: 2008
Current Diagnosis: In Remission
Treatment Received: Bone replacement, SCT, Velcade, Revlimid, Ninlaro

I was diagnosed with Multiple Myeloma when I was 26 years old. I was a bit lost at first because I was very young when I received this diagnosis, but I soon realized that everyone experiences it differently. Since my diagnosis, I’ve had to cut back on a lot of physical things I used to do, like exercising. I’ve learned how to manage my energy and put it towards things that matter most to me. I am very motivated to share my experiences with others battling this disease and hope to empower other patients during their journey.

Annamarie K.Anna Marie K

50, from Norwalk, CT
Initially Diagnosed: Husband JP in 2014
Current Diagnosis: Relapsed, Refractory

My husband, JP, was diagnosed with multiple myeloma six years ago at the age of 48. We do whatever we can to support the MMRF and to keep a positive mindset about our situation. It has been a journey from day one, but I feel we are confident going forward. I’m thrilled to be at this point in our lives to be able to help others. I’m so appreciative of the help we’ve received, and I’m grateful for this opportunity because we understand how this journey with multiple myeloma can be overwhelming.

Carmen P.Carmen P

52, from Little Silver, NJ
Initially Diagnosed: 2002
Current Diagnosis: Relapsed, Refractory
Treatment Received: Tandem SCT, Allogenic SCT, RVD, Clinical Trial Participant

Carmen’s experience leading up to her diagnosis was unique in that she did not present any symptoms and was diagnosed via pre-pregnancy bloodwork. It revealed that she had low platelets and was anemic. At the time, Carmen was diagnosed with smoldering multiple myeloma, as she did not meet the criteria to be diagnosed with active multiple. Carmen’s multiple myeloma status continued to be smoldering for a total of 8 years until December 2010. Carmen strives to stay positive and maintain a healthy and active lifestyle. She has persevered and embraces the changes that her diagnosis has caused in her life.

Andrew G.Andrew G

67, from Harrisburg, PA
Initially Diagnosed: 2013
Current Diagnosis: In Remission
Treatment Received: SCT, RVD, Revlimid for maintenance

Andrew’s biggest challenge after receiving his diagnosis was educating himself on this disease. His healthcare team embraced his determination to educate himself, which gave him additional confidence in his doctors. Andrew has kept a  positive outlook and is self-motivating. One motivating factor he had was retirement; although, he only wanted to semi-retire. He remains an active grandfather to his two young grandsons and helps his daughter by babysitting them. He feels that his multiple myeloma journey has made him a better person in that he is more compassionate and understanding.

Jessie D.Jessie D

54, from Vermillion, SD
Initially Diagnosed: 2016
Current Diagnosis: Smoldering
Treatment Received: None at this time

Jessie is determined to not let her diagnosis define her and dominate her life; therefore, she has taken control of the situation by continuing her research and education on her diagnosis and learning the importance of practicing self-awareness and self-advocacy for her own health. She has become dedicated in her efforts to incorporate being health-conscious in her lifestyle. Prior to her diagnosis, Jessie’s sense of self was connected to her career. Now, she's revisiting this and learning how to reinvent herself and the lifestyle she plans to lead.

Jeffery G.Jeffrey G

59, from Chicago, IL
Initially Diagnosed: 2010
Current Diagnosis: Relapsed, Refractory
Treatment Received: Tandem SCT, Ninlaro, Revlimid, Velcade, Pomalyst, Darzalex

Jeffery stresses the importance of staying motivated and positive. He manages his lifestyle and nutrition to do what he can to have a full and active life. He is determined to continue his active hobbies. Before and after his diagnosis, he has continued to participate in his hobbies as a marathon runner, hunter, fisherman, and hiker. He climbed Mt. Kilimanjaro earlier this year and is taking a summer vacation with his wife to Montana to backpack and hike. Doing the things he loves helps him feel empowered against his disease. He also has found strength in becoming an active member of the multiple myeloma community. Jeffery has been extensively involved in the "mother ship" of MMRF. Jeffery is passionate about raising awareness of MMRF and helping others navigate their way and to find their path.

Daniel Auclair, PhD – Chief Scientific Officer 

Dr. Daniel Auclair is the Chief Scientific Officer for the MMRF and has been with the organization for over a decade. He is responsible for oversight of the development and execution of the organization’s scientific plan. In addition, he is responsible for all the MMRF preclinical and translational activities. Dr, Auclair is also deeply involved in the Multiple Myeloma Research Consortium (MMRC), a network of 25 multiple myeloma centers of excellence across the U.S. through which 82 multiple myeloma clinic trials have been run to date.

Dr. Auclair was selected by PharmaVoice in 2017 as one of the 100 Most Inspiring People in the life-sciences industry. After completing his graduate studies in Montreal and postdoctoral fellowship at Dana-Farber Cancer Institute/Harvard Cancer Center where he conducted seminal multiple myeloma genomic work, Dr. Auclair then spent a decade in early cancer drug discovery in biotech/pharma, mostly at Bayer where he worked, among others, on overseeing the Bayer-Millennium cancer genomics drug collaboration as well as on Nexavar and Stivarga. He also worked at the Broad Institute of MIT and Harvard where as a senior manager in the Cancer Program he was involved in a wide range of academic and industry collaborations centered around cancer genomics and precision medicine initiatives. 

Michael Andreini – President and Chief Executive Officer

 

Michael Andreini is the President and Chief Executive Officer of the Multiple Myeloma Research Foundation (MMRF) and the Multiple Myeloma Research Consortium (MMRC). Michael brings nearly 15 years of strategic consulting and operational experience in the life sciences industry. Prior to joining the MMRF, Michael was an Associate Principal at IQVIA in the consulting services organization where he developed strategies for biopharma, medical device, and non-profit organizations to drive innovation and operational excellence across a diverse set of business challenges including R&D and launch strategy, commercial due diligence and portfolio optimization, and organizational effectiveness. Before joining IQVIA, Michael worked at Fuld & Company, a boutique consulting firm specializing in competitive intelligence and strategy, and prior to that, at Siemens Healthcare Diagnostics in the Global Technical Operations group where he resolved technical issues for immunoassay reagents and systems. Michael earned a B.A. in chemistry with a minor concentration in economics from Colgate University.

 

Paul Giusti – President, Riverwoods Holdings, LLC

Paul Giusti is the former President and Chief Executive Officer of the Multiple Myeloma Research Foundation (MMRF). Prior to the MMRF, Mr. Giusti worked as a Chief Executive Officer, leader, executive and entrepreneur for over 30 years; he has founded, managed and led a variety of businesses. Early in his career, Mr. Giusti worked as an executive for GE where he held a number of management positions with a wide range of responsibilities.

Mr. Giusti has worked closely with the MMRF since its founding in 1998. In addition to chairing the successful $100 million capital campaign, he has served as a consultant for a number of foundation projects, led several MMRF outreach efforts and spoken on behalf of the MMRF.

Mr. Giusti holds a Bachelor of Science degree from the Colorado School of Mines and an MBA from Harvard University.

Learn more about Kathy

Kathy Giusti – Founder and Chief Mission Officer 

Faculty Co-Chair, HBS Kraft Precision Medicine Accelerator
Harvard Business School

Kathy Giusti, a multiple myeloma patient, is the Founder of the Multiple Myeloma Research Foundation (MMRF) and the Multiple Myeloma Research Consortium (MMRC). She is also the Chief Mission Officer of the MMRF. Kathy is the Henry & Allison McCance Family Senior Fellow at Harvard Business School, where she serves as Faculty Co-Chair of the HBS Kraft Precision Medicine Accelerator. Kathy has more than two decades of experience in the pharmaceutical industry, previously holding senior positions at G.D. Searle and Merck.

Since founding the MMRF in 1998, Kathy has become a widely respected leader in establishing innovative, collaborative research models in the areas of tissue banking, genomics, and clinical trials. These models are dramatically accelerating the pace at which lifesaving treatments are brought to patients and are building an end-to-end solution in precision medicine. Today, she is recognized as a pioneer of precision medicine, a champion of data sharing, and a strong advocate for patient engagement.

In 2016, Kathy was named Faculty Co-Chair of the Harvard Business School (HBS) Kraft Precision Medicine Accelerator, a $20 million program endowed by Robert Kraft and the Kraft Family Foundation. Under her leadership, the HBS Kraft Precision Medicine Accelerator convenes best-in-class leaders from science, business, and technology to identify and solve challenges slowing the advancement of precision medicine. The HBS Kraft PM Accelerator disseminates best practices and models to overcome these challenges, and ultimately enables faster adoption of high-impact innovations.

Kathy has earned numerous prestigious awards and recognitions, including being named 1 of 3 Top Business Leaders Disrupting Medicine by Fortune Magazine and #19 on Fortune’s World’s 50 Greatest Leaders list. She was also named one of the world’s 100 Most Influential People by TIME magazine. Kathy received the Open Science Champion of Change award by the White House. In addition, she has been honored with the American Association for Cancer Research Centennial Medal for Distinguished Public Service and the Healthcare Businesswomen’s Association’s Woman of the Year Award.

Kathy serves on the advisory boards of Verily and Verily’s Project Baseline and is a member of the Harvard Business School (HBS) Health Advisory Board. She a Member of the FasterCures Non-Profit Council. Kathy previously served on President Obama’s 2015 Precision Medicine Initiative Working Group, the President’s Council of Advisors on Science and Technology (PCAST), National Cancer Advisory Board (NCAB), and the National Cancer Policy Board (NCBP).

Kathy has been featured on the Today Show, NBC Nightly News, CBS Evening News, Fox News, CNN, and Bloomberg. Her efforts have also been profiled by Fortune, The Wall Street Journal, Harvard Business Review, The New York Times, Forbes, The New Yorker, WIRED, and Fast Company.

Kathy received her MBA in general management from Harvard Business School and holds an honorary Doctorate from the University of Vermont.

 

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Nicole Sandilands

RN, BSN, OCN

Nicole has been a registered nurse for five years, specializing in oncology and palliative care. She began her career as an inpatient oncology nurse at Yale providing bedside care to patients and then transitioned to Norwalk Hospital where she worked as a chemotherapy infusion nurse. She received her nursing degree from Fairfield University and is currently pursuing her doctorate in nursing practice (DNP). Her research focus is on “Chemo Brain” which is studying the cognitive changes experienced from receiving chemotherapy.

 

William_McKiernan_BW

William S. McKiernan

President
WSM Capital, LLC

Bill McKiernan is president of WSM Capital, LLC, a private equity firm he founded to invest in payment and other technology companies. Prior to founding WSM Capital, Bill founded CyberSource Corporation in 1994. CyberSource provides payment processing and other related services to online businesses. He was Chairman and CEO for 16 years. In July 2010, Visa, Inc. acquired CyberSource in a transaction valued at $2 billion. Mr. McKiernan served as Executive Advisor to Visa, Inc. for two years following the acquisition before founding WSM Capital in 2012.  

Mr. McKiernan holds a BS from Boston College and an MBA from the Harvard Business School. Prior to founding CyberSource he held positions at Price Waterhouse, IBM, and McAfee Associates.

In addition to the MMRF, he serves on the boards of trustees of Boston College, Bellarmine College Prep, and American Ireland Fund and is a member of Harvard Business School Global Advisors.

Mindy Flinn, MBA – Vice President of Development

Mindy Flinn joined the MMRF in May 2020 as the Vice President of Development where she works with a talented team raising philanthropic support for the organization. She brings over 23 years of development experience to this position. Ms. Flinn spent over a decade in development at Mayo Clinic in Rochester, MN and in Jacksonville, FL, where she oversaw the stewardship of top-level benefactors and served as a major gift officer. She also worked for the LIVESTRONG Foundation in Austin, TX as a major gift officer and was Director of Philanthropic Resources at MD Anderson Cancer Center in Houston, TX. Prior to joining the MMRF, she was Senior Director of Development at Yale School of Medicine. Ms. Flinn received her Bachelor of Science in Biology from Bethel University and a Master of Business Administration from Cardinal Stritch University. Her additional accomplishments include successfully climbing Mt. Kilimanjaro in 2012 as a member of Survivor Summit and skydiving. 

Greg Rubenstein - Vice President of Marketing and Communications

Greg Rubenstein is the VP of Marketing & Communications at the MMRF, where he leads all brand marketing strategy and execution in support of the organization.

Prior to joining the MMRF, Greg spent the majority of his career working for Advertising firms like Grey NY, Saatchi & Saatchi, FCB Health, and Deutsch -- servicing clients across a wide variety of sectors, including Healthcare, Technology, Financial Services, and Consumer Packaged Goods. He has brought to market countless products and campaigns over nearly 20 years, including high-profile healthcare launches in Vaccines and Women’s Health. In 2013 he joined a technology startup called Vettery, where he helped to launch the brand and all of its communications while serving as the company’s Chief Client Officer & lead brand strategist.

Greg is a graduate of Cornell University, with a B.S. in Psychology & Human Development. He resides in Irvington, NY with his wife and two sons.

Kristen Donadio

RN, BSN

Kristen has been a registered nurse for a little over 20 years. She spent the last 18 of those years working at the John Theurer Cancer Center (JTCC) in various nursing positions in both the Myeloma and Bone Marrow transplant clinics. Her last 2 years at JTCC were spent as the Administrative Supervisor of the Myeloma Division. She graduated from Stockton University with a degree in Public Health Administration, followed by an Accelerated Bachelor’s of Science in Nursing degree from Fairleigh Dickinson University. She is a member of the Oncology Nursing Society and she holds a certification in chemotherapy/biotherapy/immunotherapy administration. She is currently working towards her master’s degree in Healthcare Administration.

Sarah Coulter

RN, OCN

Sarah has been a registered nurse for the past five years, specializing in Hematology Oncology and Bone Marrow Transplant. She has spent over ten years in the Oncology field and started her career at Yale New Haven Hospital. Over the last three years, Sarah worked as a traveling nurse in California, South Carolina, Florida, Texas and Maryland. She earned her nursing degree from St. Vincent’s School of Nursing. She is chemotherapy certified and is currently in school to obtain her master’s degree in nursing education.

 

Meryl Zausner

Former Chief Financial Officer
Novartis Corporation

Meryl Zausner has over 35 years of management experience across the pharmaceutical and consumer products industries. Meryl was instrumental in creating the blueprint for the successful Novartis Oncology Business Unit and engineering the launch of the first Novartis shared services organization.  A recognized developer of diverse talent, The Healthcare Businesswomen Association honored Meryl with its prestigious Woman of the Year Award.

For much of her corporate career, Meryl worked at Novartis AG, the Swiss pharmaceuticals company, in roles of increasing responsibility across diversified businesses. From April 2012 through 2014, Meryl was Chief Financial and Administrative Officer of Novartis Pharmaceuticals Corporation in the US, and a member of the Pharmaceutical Executive Committee and Global Finance Leadership Team. While in this role, Meryl also resumed responsibility as Chief Financial Officer and Executive Vice President of Novartis Corporation in the US.

Acknowledging her strong leadership and broad achievements, Novartis selected Meryl to train and serve as a certified Executive Coach to senior executives, a position she held from May 2015 until her retirement at the end of June 2017.  She has a BS in Economics and Accounting from the University at Albany and her CPA.

Meryl is a Board member and Chair of the Audit Committee of the Multiple Myeloma Research Foundation, and Board member of Deirdre’s House, an advocacy center for children who are victims of abuse or neglect.  Former board positions include HBA Advisory Board, PhRMA Audit and Finance Subcommittee member, and the T.J. Martell

Foundation. PharmaVoice magazine recognized Meryl among its Most Inspiring, and she received Gilda Club’s Red Door Honoree. Meryl resides with her husband in Naples, Florida and Long Branch, New Jersey.

Steven Shak, MD

Co-Founder, Chief Scientific Officer
Genomic Health

Dedicated to optimizing cancer treatment outcomes and bringing the patient voice into product development, Steve Shak, M.D. has served as the Co-Founder and Chief Scientific Officer of Genomic Health since 2012, and was the Chief Medical Officer from 2000 – 2013. Under Steve’s leadership Genomic Health used innovative molecular diagnostic methods and rigorous clinical studies to develop the Oncotype DX® breast cancer and colon cancer assays and has maintained an 80% product development success rate. Steve has been a leader in personalized medicine for more than two decades.

Prior to co-founding Genomic Health in 2000, Steve served for 14 years in various roles in Discovery Research and Medical Affairs at Genentech, Inc., a biotechnology company dedicated to using human genetic information to discover, develop, manufacture and commercialize medicines to treat patients with serious or life-threatening medical conditions. Steve led the clinical team that gained approval for Herceptin®, a targeted biologic treatment for breast cancer. He also initiated the cancer clinical trials of the anti-angiogenesis agent, Avastin®.

In addition, Steve discovered Pulmozyme®, a mucus-dissolving enzyme that is approved worldwide for the treatment of the genetic disease cystic fibrosis.

Prior to joining Genentech, Steve was an Assistant Professor of Medicine and Pharmacology at New York University School of Medicine.

Steve holds a Bachelor of Arts degree in Chemistry from Amherst College and an M.D. from New York University School of Medicine, and completed his post-doctoral training at University of California, San Francisco.

Rodger Riney

Former CEO and Founder
Scottrade

Rodger Riney grew up in Kirkwood, Missouri, and graduated from the University of Missouri with a Civil Engineering degree and an MBA.

In 1969, he joined Edward D. Jones & Co. in Saint Louis and later became a partner. In 1980, he left to enter the relatively new discount brokerage industry by starting Scottrade. Over the years, Scottrade evolved into an online brokerage and bank supporting its 3 million clients through 500 branch offices nationwide.

In the fall of 2015, Rodger was diagnosed with multiple myeloma and in late 2017, Scottrade was sold to TD Ameritrade.

In 2019, Mr. Riney started Lightchain Capital LLC, with a focus on various capabilities investing in early-stage biotech technologies with an emphasis on therapeutics for blood cancer and multiple myeloma.

Michael Reinert

Partner
Fox Rothschild LLP

Michael Reinert is a leading music industry attorney who most recently served as Executive Vice President of Business & Legal Affairs for the Universal Motown Republic Group, a division of UMG Recordings, Inc. In that position, he had the pleasure of working with great talent such as Stevie Wonder, Elton John, Taylor Swift, Amy Winehouse, Lil Wayne, Nelly, Jack Johnson and many other platinum selling acts.

Prior to joining Universal ten years ago, Michael was the Vice President of Business & Legal Affairs for PolyGram Records, handling those duties for the legendary Verve Records label and Mercury Nashville Records where he worked with the likes of Herbie Hancock and Shania Twain. Michael started his career in private practice representing many artists, producers and writers before joining the corporate ranks.

Michael was an Adjunct Professor of Law at his alma mater, The Benjamin Cardozo School of Law of Yeshiva University, for ten years teaching Contract Drafting and Negotiation in the Music Industry. He has been a contributing editor to the Practicing Law Institute volumes on the same subject and continues to lecture at various schools and seminars around the country.

He currently serves as the Chairman of the Entertainment Law Initiative of the Grammy Foundation, a division of the National Academy of Recording Arts and Sciences, which focuses on legal education programs for aspiring entertainment attorneys.

Michael attended the Horace Mann School for Boys in Riverdale and Tulane University in New Orleans, a place he considers his second home. He lives in Manhattan with his wife of 30 years, Karen. They have a daughter and two beautiful grandchildren.

Marie E. Pinizzotto, M.D., MBA

President and CEO
Carol A. Ammon Foundation

Marie E. Pinizzotto, M.D., MBA, is currently the President and CEO of the Carol A. Ammon Foundation, a foundation focused on health care and education. Prior to running the foundation, she was president of Drug Safety Solutions, L.L.C., a Pharmacovigilance and Risk Management consulting company whose main focus was narcotics and other high-risk drugs.  Prior to starting her own company she worked at Endo Pharmaceuticals Inc. where she was Senior Director of the Global Safety and Pharmacovigilance department.  In this role she was responsible for pharmacovigilance of all Endo products, marketed and investigational. Marie was also responsible for the safety components in the following disciplines; Clinical Research, Medical Affairs and Clinical Education and Development. In addition, she led the Risk Management Team and was responsible for the creation and implementation of Endo’s risk management programs. Additionally, she was Senior Director of Report Evaluation and Safety Surveillance for the Women’s Health Division and Consumer Products at Wyeth. 

Dr. Pinizzotto received her B.S in Chemistry, magna cum laude, from the University of Pittsburgh, Pittsburgh Pennsylvania and her medical degree from Jefferson Medical College (now Sidney Kimmel Medical College)in Philadelphia. She completed her residency at The Medical Center of Delaware, where she practiced obstetrics and gynecology for nine years. She still maintains privileges at the hospital.  Most recently, Dr. Pinizzotto earned her MBA at the University of Delaware.

Currently, Dr. Pinizzotto is the named Chair of Obstetrics and Gynecology at Christiana Care Hospital, Newark, Delaware, and is also a trustee of the hospital.  She is a member of the finance committee and has participated on the Quality and Safety Committee at Christiana Care Health Systems.

In addition, she is a board member at Eisenhower Medical Center, Rancho Mirage, California, and also sits on the quality improvement committee. Marie is named Chair, The Marie E. Pinizzotto, MD Chair of Academic Affairs, at Eisenhower Medical Center.

Dr. Pinizzotto is a director of The Carol A. Ammon Foundation, The Multiple Myeloma Research Foundation and the Palm Springs International Film Festival. She also participates on the following advisory boards:  Scientific Steering Committee on Personalized Medicine for the Multiple Myeloma Research Foundation; The Presidents Leadership Council  of the University of Delaware, the Presidents Leadership Council at Jefferson Medical College and she is one of the founding members of the MGH Leadership Council for Psychiatry at Massachusetts General.

David R. Parkinson, MD

Chairman of the Clinical Advisory Board
Zyngenia. Inc.

From 2007 until 2012, Dr. Parkinson served as President and CEO of Nodality, a South San Francisco-based venture-financed biotechnology company developing technologies to enable personalized medicine and more efficient drug development in cancer and autoimmune diseases.

Before joining Nodality, Dr. Parkinson was Senior Vice President, Oncology R&D, at Biogen Idec, overseeing oncology discovery research efforts and the development of the oncology pipeline. Previously he had served tenures as Vice President and Head of the Oncology Therapeutic Area at Amgen and Vice President and Head of Global Clinical Oncology Development at Novartis. During his tenures at Amgen and Novartis, Dr. Parkinson was responsible for clinical development activities leading to a series of successful global drug registrations for important cancer therapeutics, including Gleevec®, Femara®, Zometa®, Kepivance®, and Vectibix®.

He received his M.D. from the University of Toronto Faculty of Medicine in 1977, with Internal Medicine and Hematology/Oncology training at McGill University and at New England Medical Center. Dr. Parkinson has authored more than 100 peer-reviewed scientific papers, and is a past Chairman of the Food & Drug Administration (FDA) Biologics Advisory Committee as well as a recipient of the FDA’s Cody Medal.

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Gerald McDougall

Partner
PricewaterhouseCoopers LLP

Mr. McDougall is Partner at PricewaterhouseCoopers Health Sciences Practice, where he provides services to academic medical centers, bioscience companies, pharmaceutical companies, research universities, colleges, health systems, and other research organizations. His practice provides a broad range of research business and compliance services, including strategic and business planning, financial analysis, research compliance, clinical research operations improvement, and information systems implementation services.

In addition, his practice provides support services to the entire research continuum, from grant-funded basic science research, to translational research and clinical trials, including a dedicated group focusing on Clinical Research Consulting services.

Susan Marvin

Chair of the Board – The Marvin Companies

Susan Marvin, Chair of the Board of The Marvin Companies, was part of the third-generation management team in what is today a fourth-generation family owned and operated company.

Active in both profit and nonprofit boards, Susan serves on The Marvin Companies Board of Directors, M. A. Mortenson Company Board of Directors, the Multiple Myeloma Research Foundation (MMRF) Board of Directors, the National Association of Manufacturers Board of Directors, the University of Minnesota Foundation Board of Trustees and she is Chair of the Minnesota Chamber Foundation Board. She is a member of the Young Presidents’ Organization (YPO) Gold.

Prior to her current role, Susan was President of Marvin Windows and Doors where she oversaw the fenestration business.

Susan is a 1979 graduate of the University of Minnesota where she earned an undergraduate degree in Journalism.  A native of Warroad, Minnesota, Susan now lives in both Warroad and Minneapolis with her husband, Keith Schwartzwald.

Hugh Martin

Vice President of Strategy, Smart Communities
Verizon

Hugh Martin joined Verizon through the acquisition of Sensity Systems by Verizon in October 2016. Hugh created the vision for Sensity Systems and the Light Sensory Network and is responsible for steering the company’s strategic course. His 35-year track record as an entrepreneurial leader of cutting-edge technology companies, new ventures, and high-growth businesses includes serving at the helm of numerous highly successful organizations. In 2011, he was named CEO for Fortune magazine’s ‘Executive Dream Team: The startup edition,’ acknowledged for his ‘management chops’ and for successfully taking public two companies, in two different industries. Most recently, the World Economic Forum recognized Hugh and Sensity as a Technology Pioneer.

Prior to Sensity, Hugh was chairman and CEO of Pacific Biosciences, a leading company in third-generation DNA sequencing. He founded Pacific Biosciences in 2004 with a team from Cornell University and piloted the company through its IPO in 2010 and commercialization in 2011. Before that, he was chairman, president, and CEO of ONI Systems, a high-speed optical telecommunications systems company he founded in 1998 and took public in 2000. Named the Fastest Growing Company in Silicon Valley in 2001, ONI was sold to Ciena in 2002; Hugh then served as a consultant to Ciena.

During his career, Hugh also was president and director of 3DO, an interactive gaming company; served as a CEO-in-residence at the venture capital firm of Kleiner Perkins Caufield & Byers; and ran desktop engineering for Apple Computer. Earlier, he founded Ridge Computers, designer of the world’s first commercial reduced instruction set computing (RISC) minicomputer.

He earned a BS in electrical engineering from Rutgers, the State University of New Jersey-New Brunswick.

David L. Lucchino

Co-Founder, President and Chief Executive Officer
Frequency Therapeutics

David has played an integral role in launching, building and operating several successful companies in the life sciences. In 2014, he, along with Robert S. Langer at the Massachusetts Institute of Technology and other co-founders, started Frequency Therapeutics with the goal of developing regenerative medicines based on discoveries related to activating progenitor cells.

Before Frequency, David was President and Chief Executive Officer of Entrega Bio, a PureTech Health-founded biotechnology company focused on oral drug delivery technology. Prior to that, David co-founded, also with Dr. Langer, Semprus BioSciences. At Semprus, David oversaw the development of the company’s lead medical product, which focused on surface modifications designed to reduce infection and clotting, and which received FDA and European CE marketing clearance. Semprus was acquired in 2012 by Teleflex, Inc. Prior to Semprus, David worked at the investment firm Polaris Partners.

David currently serves as the Chairman of the Board of Directors of MassBio. He is a member of the College of Fellows of the American Institute for Medical and Biological Engineering and was appointed by Governor Charlie Baker to the Commonwealth’s Science, Technology, Engineering and Math Advisory Council. He also serves as a trustee of Mt. Auburn Hospital, a Harvard Medical School facility, a trustee of the Multiple Myeloma Research Foundation, and a member of the Board of Advisors of Life Science Cares.

David earned a B.A. from Denison University, an M.S. from the Newhouse School of Journalism at Syracuse University and an M.B.A. from the MIT Sloan School of Management as an Alfred P. Sloan Fellow.

Dana LaForge

Partner
Brera Capital Partners, LLC

Dana LaForge is a Partner at Brera Capital Partners, a private equity fund, and the Founder and Managing Partner of Colonnade Financial Group, a private equity services firm.

Prior to Brera and Colonnade, Dana was head of Financial Institutions Investment Banking and Chief of Staff of Banking and Capital Markets at Deutsche Bank and its predecessor companies. Earlier in his career, he was a bond trader and founded the Mortgage Finance Group.

Dana has served on numerous portfolio company boards and is the Chairman of GAB Robins NA. He was one of the earliest Directors of the Multiple Myeloma Research Foundation joining the Board in 1999 and helping guide the Foundation from start up through today serving as the organization’s only Chairman since being elected in 2003.

Dana earned a BS from Washington and Lee University and an MBA from Harvard Business School. He lives in New York City with his wife, Kathleen McCabe and their two daughters.

Rodney Gilmore

Corporate and Business Law
Doty Barlow Britt & Theiman LLP

Rodney Gilmore is an attorney in the California Bay Area and a longtime college football broadcaster.

Gilmore joined ESPN in August of 1996 as a college football analyst. He currently works on ESPN/ABC Saturday telecast and contributes to studio shows including College Football Live, Outside the Lines and SportsCenter. He previously served as an ESPN studio analyst and a contributor to ESPN.com and ESPN The Magazine (out of print as of 2019).

Prior to joining ESPN, Gilmore worked as an analyst with Prime Sports Network in California (1993-95), covering Pac-10 football, along with SportsChannel Bay Area from 1991-93 and the Pacific Sports Network in 1990. He was nominated for an Emmy Award in 1994 for live sports coverage of Pac-10 football.

A 1982 Stanford University graduate with a degree in English, Gilmore was a defensive back under coaches Bill Walsh, Rod Dowhower, Paul Wiggin and George Seifert, and also played baseball for Stanford.

Following graduation from Stanford, he earned his law degree from the University of California at Berkeley (Boalt Hall) in 1986, and was admitted to the California State Bar the same year.  He began his law career in Los Angeles with the firm of Manatt Phelps & Phillips, LLP before returning to the Bay Area in 1988. He became a partner in the San Francisco business law firm Greene Radovsky Maloney & Share LLP in 1993. In 1997, he joined the Palo Alto, CA business law firm of Doty, Barlow, Britt & Thieman LLP. Rodney specializes in transactional law with an emphasis on business formation and planning, mergers and acquisitions, and commercial transactions. He also has extensive experience in commercial real estate matters, including sales and acquisitions, financings and leases.

Gilmore is a longtime volunteer for Stanford. He is a member and former officer of two entities sponsored by the Stanford Alumni Association. He previously served as chairman of the Stanford Athletic Board and as a member of the Board of Directors of the Stanford Alumni Association. He is also an active member of several Bar Associations and several local community organizations.

An Oakland, CA native, Gilmore is a member of the Oakland Babe Ruth Baseball Hall of Fame. He lives in the Bay Area with his wife, Marie, the former Mayor of Alameda, CA, and has two adult children (Anthony and Nicole).

Thomas Conheeney

Retired President
SAC Capital

Tom was appointed President of SAC Capital in July 2008. He joined SAC in October 1999 as Chief Operating Officer.

Prior to joining SAC, Tom was President of Investment Management Services, Inc (“IMS”) from 1996 to 1999. He joined Moore Capital /IMS in 1993 and served as its Director of Trading Operations and then Vice President until IMS split off from Moore in 1995. Tom joined Moore Capital /IMS from Goldman Sachs Trust Company, where he was a Vice President with responsibilities for daily operations, technology, and client services. From 1986 to 1993, Tom was in the operations and equity divisions of Goldman, Sachs & Co., becoming Vice President in 1991.

He retired from SAC December 2014.

Karen E. Andrews

Karen E. Andrews

Senior Vice President and General Counsel
March of Dimes

Karen E. Andrews is currently SVP and General Counsel for the March of Dimes. Previously Karen was the General Counsel and Corporate Secretary of BBDO Worldwide, Inc. where she was responsible for the management of the legal activities of over 150 individual operating units throughout the world.

Prior to joining BBDO Worldwide, Ms. Andrews was Associate General Counsel and Director of Television Business Affairs at Time Inc. Ms. Andrews began her career in law as a Litigation Associate at the New York law firm of Weil, Gotshal & Manges where she specialized in Entertainment Litigation.

Ms. Andrews graduated cum laude from the University of Vermont with a Bachelor of Science degree in biology and earned her law degree, cum laude, from Temple School of Law.

Ms. Andrews is a member of the American Bar Association and the New York State Bar Association.

In 1998, Ms. Andrews co-founded the Multiple Myeloma Research Foundation with Kathy Giusti.

Kenneth Anderson, MD

Director
Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute

Dr. Anderson graduated from Johns Hopkins Medical School. He trained in internal medicine at Johns Hopkins Hospital and completed hematology, medical oncology, and tumor immunology training at the Dana-Farber Cancer Institute.

Dr. Anderson is the Kraft Family Professor of Medicine at Harvard Medical School and serves as Chief of the Division of Hematologic Neoplasia, Director of the Jerome Lipper Multiple Myeloma Center, and Vice Chair of the Joint Program in Transfusion Medicine at the Dana-Farber Cancer Institute.

He received the Waldenstrom’s Award in 2003 for his translational research directed to the development of novel therapeutics targeting the myeloma cell in its microenvironment and is a Doris Duke Distinguished Clinical Research Scientist.

In addition to serving on the Board of Directors of the MMRF, Dr. Anderson serves as Chairman of the MMRF’s Scientific Advisory Committee, Chairman of the Multiple Myeloma Research Consortium, and Chairman of the National Comprehensive Cancer Network’s Multiple Myeloma Clinical Practice Guidelines Committee.