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- Immune response
Reaction occurring within the body to defend against foreign invaders.
- Immune system
Network of related cells, tissues and organs that protect the body from disease organisms, other foreign bodies and cancers.
- Immunoelectrophoresis
See Immunofixation electrophoresis.
- Immunofixation electrophoresis (IFE)
Type of electrophoresis that uses a special antibody staining technique to identify specific types of immunoglobulin and light chains; also called immunoelectrophoresis.
- Immunoglobulin
Protein produced by a plasma cell that is generated in reaction to a foreign protein (antigen), thus producing an immunity against that protein; also known as an antibody. Immunoglobulins are made up of 2 heavy chains and 2 light chains that form a “Y”-like structure and can be of the IgA,(...) - Immunomodulatory agent
Drug that affects, enhances or suppresses the immune system.
- Immunomodulatory drugs or IMiDs®
Drugs that work to fight cancer cell growth by impacting the functioning of the immune system.
- Immunosuppressive drug
Drug given to suppress a patient’s immune system, such as one given to prevent rejection of transplanted tissue.
- Immunotherapy
The treatment of, or prevention against, a disease achieved through manipulation of the patient’s immune system.
- Induction therapy
Initial therapy for myeloma. This term also refers to the use of anti-myeloma drugs prior to high-dose chemotherapy and stem cell transplant in order to reduce the tumor burden.
- Infusion Reaction
Possible side effect seen with some drugs that are given intravenously. Symptoms are usually mild to moderate and most commonly include chills, fever, nausea, weakness, headache, skin rash and/or itching. In most cases, these reactions can be managed by either slowing or stopping the(...) - Institutional Review Board (IRB)
Board designed to oversee the research process in order to protect participant safety. Made up of researchers, ethicists and lay people from the community, the board must review clinical trial protocols and the informed consent forms participants sign.
- Interferon (IFN)
Substance naturally produced in the body by virus-infected cells that protects noninfected cells from viral infection. Interferon also has various effects on the immune system and is used in the treatment of several cancers and infectious diseases.
- Interleukin 1 beta (IL-1b)
Cytokine that enhances the growth and survival of B cells and myeloma cells and promotes inflammation.
- Interleukin 2 (IL-2)
Cytokine (growth factor) produced by T-cells that stimulates the growth of T cells and B cells.
- Interleukin 4 (IL-4)
Cytokine that enhances the immune system’s ability to fight tumor cells.
- Interleukin 5 (IL-5)
A potent T-cell derived factor that stimulates the growth of B-cells.
- Interleukin 6 (IL-6)
Cytokine that promotes the growth and survival of myeloma cells and normal B cells.
- Interleukin 8 (IL-8)
Cytokine secreted by bone marrow stromal cells in myeloma patients that promotes formation of osteoclasts (bone degrading cells).
- Interleukin 10 (IL-10)
Cytokine involved in the growth and survival of myeloma cells.
- Interleukin 12 (IL-12)
Cytokine that promotes T cell function and tumor cell killing.
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